Chemical Structure
15-Lipoxygenase 1, Inhibitor
15-Lipoxygenase Inhibitor 1
Purity
0.9875
Synonyms
15-Lipoxygenase 1; 15-Lipoxygenase Inhibitor 1; 4-MMPB; inhibitor
Purity/Purification
0.9875
Form/Format
Solid
Solubility
DMSO: 8mg/mL (25.52mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
SMILES
CC1=C2C(=NC(=N1)N3CCN(CC3)C)SC4=CC=CC=C4N2
Formula
C16H19N5S
CAS Number
928853-86-5
Preparation and Storage
Store at 0-4 degree C for short term (days to weeks), or -20 degree C for long term (months).
Chemical Structure
Chemical Structure
Related Product Information for 15-Lipoxygenase 1, inhibitor
15-Lipoxygenase Inhibitor 1 is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18uM. 4-MMPB has IC50s of 19.5uM and 19.1uM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively. 4-MMPB has potential for the research of prostate cancer.
References
Nikpour M, Mousavian M, Mahdieh Davoodnejad. Synthesis of new series of pyrimido[4,5- b ][1,4] benzothiazines as 15-lipoxygenase inhibitors and study of their inhibitory mechanism[J]. Medicinal Chemistry Research, 2013, 22(10):5036-5043.
Saboormaleki S, Sadeghian H, Bahrami A R, et al. 7-Farnesyloxycoumarin Exerts Anti-cancer Effects on a Prostate Cancer Cell Line by 15-LOX-1 Inhibition[J]. Archives of Iranian Medicine, 2018, 21(6):251-259.
Alavi S J, Sadeghian H, Seyedi S M, et al. A novel class of human 15-LOX-1 inhibitors based on 3-hydroxycoumarin[J]. Chemical Biology & Drug Design, 2018.
Saboormaleki S, Sadeghian H, Bahrami A R, et al. 7-Farnesyloxycoumarin Exerts Anti-cancer Effects on a Prostate Cancer Cell Line by 15-LOX-1 Inhibition[J]. Archives of Iranian Medicine, 2018, 21(6):251-259.
Alavi S J, Sadeghian H, Seyedi S M, et al. A novel class of human 15-LOX-1 inhibitors based on 3-hydroxycoumarin[J]. Chemical Biology & Drug Design, 2018.
Similar Products
Product Notes
The 15-Lipoxygenase 1 (Catalog #AAA5764966) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "15-Lipoxygenase 1, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
