INHA recombinant protein

INHA, 233-366aa, Human, His tag, E Coli (Denatured)

Cat. Num. AAA205275

• Applications: SDS-Page
• Purity: > 85% by SDS-PAGE
• Synonyms: INHA; 233-366aa; Human; His tag; E Coli (Denatured); inhibin alpha chain; A inhibin subunit precursor; IHA; INHA recombinant protein

• Host: E Coli
• Purity/Purification: > 85% by SDS-PAGE
• Form/Format: Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.4M urea, 10% glycerol
• Concentration: 0.5 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MSTPLMSWPW SPSALRLLQR PPEEPAAHAN CHRVALNISF QELGWERWIV YPPSFIFHYC HGGCGLHIPP NLSLPVPGAP PTPAQPYSLL PGAQPCCAAL PGTMRPLHVR TTSDGGYSFK YETVPNLLTQ HCACI
• Sequence Length: 366

• Applicable Applications for INHA recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for INHA recombinant protein

INHA, also known as Inhibin alpha, belongs to the TGF-beta family. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Recombinant human INHA protein, fused to His-tag at N-terminus, was expressed in E Coli.

Product Categories/Family for INHA recombinant protein

Signal Transduction

References

Knight, P.G. (1996) Front. Neuroendocrinol. 17: 476-509.; Mather, J.P., et al. (1997). Proc. Soc. Exp. Biol. Med. 215: 209-222.;

NCBI and Uniprot Product Information

• NCBI GI #: 4504697
• NCBI GeneID: 3623
• NCBI Accession #: NP_002182
• NCBI GenBank Nucleotide #: NM_002191.3
• UniProt Accession #: P05111; A8K8H5
• Molecular Weight: 17.0kDa (155aa)
• NCBI Official Full Name: inhibin alpha chain preproprotein
• NCBI Official Synonym Full Names: inhibin alpha subunit
• NCBI Official Symbol: INHA
• NCBI Protein Information: inhibin alpha chain
• UniProt Protein Name: Inhibin alpha chain
• Protein Family: Inhibin
• UniProt Gene Name: INHA

NCBI Description

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. Mutations in this gene may be associated with male infertility and premature ovarian failure in female human patients. [provided by RefSeq, Aug 2016]

Uniprot Description

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.