Interleukin enhancer-binding factor 2 (ILF2) Recombinant Protein | ILF2 recombinant protein

Recombinant Human Interleukin enhancer-binding factor 2 (ILF2)

Cat. Num. AAA1483851

• Gene Names: ILF2; NF45; PRO3063
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Interleukin enhancer-binding factor 2 (ILF2); Recombinant Human Interleukin enhancer-binding factor 2 (ILF2); ILF2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-390, Full length protein
• Sequence: MRGDRGRGRGGRFGSRGGPGGGFRPFVPHIPFDFYLCEMAFPRVKPAPDETSFSEALLKRNQDLAPNSAEQASILSLVTKINNVIDNLIVAPGTFEVQIEEVRQVGSYKKGTMTTGHNVADLVVILKILPTLEAVAALGNKVVESLRAQDPSEVLTMLTNETGFEISSSDATVKILITTVPPNLRKLDPELHLDIKVLQSALAAIRHARWFEENASQSTVKVLIRLLKDLRIRFPGFEPLTPWILDLLGHYAVMNNPTRQPLALNVAYRRCLQILAAGLFLPGSVGITDPCESGNFRVHTVMTLEQQDMVCYTAQTLVRILSHGGFRKILGQEGDASYLASEISTWDGVIVTPSEKAYEKPPEKKEGEEEEENTEEPPQGEEEESMETQE
• Sequence Length: 390

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for ILF2 recombinant protein

Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the smaller of which is the product of this gene. The encoded protein binds strongly to the 90 kDa protein and stimulates its ability to enhance gene expression.

NCBI and Uniprot Product Information

• NCBI GI #: 392513662
• NCBI GeneID: 3608
• NCBI Accession #: NP_001254738.1
• NCBI GenBank Nucleotide #: NM_001267809.1
• UniProt Accession #: Q12905; Q5SR10; Q5SR11; Q7L7R3; Q9BWD4; Q9P1N0; A6NDB0; B2R8G7
• Molecular Weight: 43,062 Da
• NCBI Official Full Name: interleukin enhancer-binding factor 2 isoform 2
• NCBI Official Synonym Full Names: interleukin enhancer binding factor 2
• NCBI Official Symbol: ILF2
• NCBI Official Synonym Symbols: NF45; PRO3063
• NCBI Protein Information: interleukin enhancer-binding factor 2
• UniProt Protein Name: Interleukin enhancer-binding factor 2
• Protein Family: Interleukin enhancer-binding factor
• UniProt Gene Name: ILF2
• UniProt Synonym Gene Names: NF45

NCBI Description

The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The encoded 45 kDa protein (NF45, ILF2) forms a complex with the 90 kDa interleukin enhancer-binding factor 3 (NF90, ILF3), and this complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm, to repair DNA breaks by nonhomologous end joining, and to negatively regulate the microRNA processing pathway. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14. [provided by RefSeq, Dec 2014]

Uniprot Description

Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus.