Interleukin-6 receptor subunit beta (Il6st) Recombinant Protein | Il6st recombinant protein
Recombinant Rat Interleukin-6 receptor subunit beta (Il6st), partial
Gene Names
Il6st; Gp130; Ac1055; Il-6rb
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Interleukin-6 receptor subunit beta (Il6st); Recombinant Rat Interleukin-6 receptor subunit beta (Il6st); partial; Il6st recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
23-618
Sequence
QLVEPCGY IYPEFPVVQR GSNFTATCVL KEKCLQVYSV NATYIVWKTN HVAVPKEQVT VINRTASSVT FTDVVFQNVQ LTCNILSFGQ IEQNVYGITI LSGYPPDIPT NLSCIVNEGK NMLCQLDPGR ETYLETNYTL KSEWATEKFP DCRTKHGTSS CMMGYTPIYF VNIEVWVEAE NALGNVSSEP INFDPVDKVK PSPPHNLSVT NSEELSSILK LAWVNSGLDS ILRLKSDIQY RTKDASTWIQ VPLEDTVSPR TSFTVQDLKP FTEYVFRIRS IKENGKGYWS DWSEEASGTT YEDRPSKAPS FWYKVNANHP QEYRSARLIW KTLPLSEANG KILDYEVVLT QSKSVSQTYT VNGTELIVNL TNNRYVASLA ARNVVGKSPA TVLTIPGSHF KASHPVVDLK AFPKDNLLWV EWTPPSKPVN KYILEWCVLS ENSPCIPDWQ QEDGTVNRTH LRGSLLESKC YLITVTPVFP GGPGSPESMK AYLKQAAPSK GPTVRTKKVG KNEAVLEWDH LPVDVQNGFI RNYSISYRTS VGKEMVVRVD SSHTEYTLSS LSSDTLYMVH MAAYTEEGGK DGPEFTFTTL KFAQGEIE
Sequence Length
596
Species
Rat
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for Il6st recombinant protein
This protein is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
102,450 Da
NCBI Official Full Name
Interleukin-6 receptor subunit beta
NCBI Official Synonym Full Names
interleukin 6 signal transducer
NCBI Official Symbol
Il6st
NCBI Official Synonym Symbols
Gp130; Ac1055; Il-6rb
NCBI Protein Information
interleukin-6 receptor subunit beta
UniProt Protein Name
Interleukin-6 receptor subunit beta
Protein Family
UniProt Gene Name
Il6st
UniProt Synonym Gene Names
IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; gp130
NCBI Description
IL-6 signal transducing molecule [RGD, Feb 2006]
Uniprot Description
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3. Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism. Has a role in embryonic development. Does not bind IL6. Essential for survival of motor and sensory neurons and for differentiation of astrocytes. Required for expression of TRPA1 in nociceptive neurons. Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation. Required for normal trabecular bone mass and cortical bone composition.
Research Articles on Il6st
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Product Notes
The Il6st il6st (Catalog #AAA955895) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 23-618. The amino acid sequence is listed below: QLVEPCGY IYPEFPVVQR GSNFTATCVL KEKCLQVYSV NATYIVWKTN HVAVPKEQVT VINRTASSVT FTDVVFQNVQ LTCNILSFGQ IEQNVYGITI LSGYPPDIPT NLSCIVNEGK NMLCQLDPGR ETYLETNYTL KSEWATEKFP DCRTKHGTSS CMMGYTPIYF VNIEVWVEAE NALGNVSSEP INFDPVDKVK PSPPHNLSVT NSEELSSILK LAWVNSGLDS ILRLKSDIQY RTKDASTWIQ VPLEDTVSPR TSFTVQDLKP FTEYVFRIRS IKENGKGYWS DWSEEASGTT YEDRPSKAPS FWYKVNANHP QEYRSARLIW KTLPLSEANG KILDYEVVLT QSKSVSQTYT VNGTELIVNL TNNRYVASLA ARNVVGKSPA TVLTIPGSHF KASHPVVDLK AFPKDNLLWV EWTPPSKPVN KYILEWCVLS ENSPCIPDWQ QEDGTVNRTH LRGSLLESKC YLITVTPVFP GGPGSPESMK AYLKQAAPSK GPTVRTKKVG KNEAVLEWDH LPVDVQNGFI RNYSISYRTS VGKEMVVRVD SSHTEYTLSS LSSDTLYMVH MAAYTEEGGK DGPEFTFTTL KFAQGEIE. It is sometimes possible for the material contained within the vial of "Interleukin-6 receptor subunit beta (Il6st), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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