Interleukin 6 Receptor (IL6R) Recombinant Protein | IL6R recombinant protein
Recombinant Interleukin 6 Receptor (IL6R)
MGHHHHHHSGSEF-AAGNVTIHW VYSGSQNREW TTTGNTLVLR DVQLSDTGDY LCSLNDHLVG TVPLLVDVPP EEPKLSCFRK NPLVNAICEW RPSSTPSPTT KAVLFAKKIN TTNGKSDFQV PCQYSQQLKS FSCQVEILEG DKVYHIVSLC VANSVGSKSS HNEA
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
NCBI and Uniprot Product Information
Uniprot Description
IL6R: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Belongs to the type I cytokine receptor family. Type 3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, cytokine
Cellular Component: extracellular space; cell surface; membrane; apical plasma membrane; extracellular region; integral to membrane; interleukin-6 receptor complex
Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-6 receptor binding; protein homodimerization activity; interleukin-6 binding; enzyme binding; ciliary neurotrophic factor receptor activity; interleukin-6 receptor activity
Biological Process: positive regulation of smooth muscle cell proliferation; cytokine and chemokine mediated signaling pathway; negative regulation of collagen biosynthetic process; positive regulation of interleukin-6 production; positive regulation of JAK-STAT cascade; endocrine pancreas development; positive regulation of chemokine production; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of MAPKKK cascade; response to cytokine stimulus; positive regulation of cell proliferation; cell growth
Research Articles on IL6R
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Product Notes
The IL6R il6ra (Catalog #AAA2009227) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Interleukin 6 Receptor (IL6R) can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the IL6R il6ra for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: The target protein is fused with N-terminal His-Tag, its sequence is listed below. MGHHHHHHSG SEF-AAGNVT IHW VYSGSQNREW TTTGNTLVLR DVQLSDTGDY LCSLNDHLVG TVPLLVDVPP EEPKLSCFRK NPLVNAICEW RPSSTPSPTT KAVLFAKKIN TTNGKSDFQV PCQYSQQLKS FSCQVEILEG DKVYHIVSLC VANSVGSKSS HNEA. It is sometimes possible for the material contained within the vial of "Interleukin 6 Receptor (IL6R), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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