SDS-Page
(Fig. SDS-PAGE analysis of Human IL36 alpha protein, N-His tag.)
IL36 alpha Recombinant Protein | IL36alpha recombinant protein
Human IL36 alpha protein
Gene Names
IL36A; FIL1; FIL1E; IL1F6; IL-1F6; IL1(EPSILON); FIL1(EPSILON)
Purity
>98% as determined by SDS-PAGE
Synonyms
IL36 alpha; Human IL36 alpha protein; Interleukin-36 Alpha; FIL1 Epsilon; Interleukin-1 Epsilon; IL-1 Epsilon; Interleukin-1 Family Member 6; IL-1F6; IL36A; FIL1E; IL1E; IL1F6; IL36alpha recombinant protein
Host
E Coli
Purity/Purification
>98% as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH7.4.
Sequence Positions
153aa
Sequence
Lys6-Phe158
Endotoxin
<0.1EU per ug of the protein as determined by the LAL method.
Protein Construction
Amino acid sequence derived from Human IL36 alpha (Q9UHA7) (Lys6-Phe158) was expressed.
Usage Notes
Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human IL36 alpha protein using the buffer we provided not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Preparation and Storage
Lyophilized Human IL36 alpha protein product should be stored desiccated below -20 degree C. Upon reconstitution, the protein should be stored at 4 degree C between 2-7 days and for future use below -20 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
SDS-Page
(Fig. SDS-PAGE analysis of Human IL36 alpha protein, N-His tag.)
SDS-Page
(Fig. SDS-PAGE analysis of Human IL36 alpha protein, N-His tag.)
Related Product Information for IL36alpha recombinant protein
Recombinant Human IL36 alpha protein expressed in E Coli.
Background: Human IL36 alpha previously called IL-1F6 and FIL1 epsilon (family of IL-1 member epsilon), is a member of the IL-1 family which includes IL-1b, IL-1a, IL-1ra, IL-18, IL-36ra (IL1F5), IL-36b (IL1F8), IL-36g (IL1F9), IL-37 (IL1F7) and IL-38 (IL-1F10). IL36a is a pro-inflammatory cytokine which plays an important role in innate and adaptive immunity. IL36a is expressed in the immune system and the fetal brain, but not in other tissues or multiple hematopoietic cell lines.IL-36 alpha, beta, and gamma all activate NF-kappa B and MAPK pathways in an IL?1 Rrp2 dependent manner, and induce production of inflammatory cytokines and chemokines such as CXCL8/IL-8. IL-36 alpha and other family members are overexpressed in psoriatic skin lesions, and transgenic overexpression of IL?36 alpha in skin keratinocytes produces epidermal hyperplasia.
Background: Human IL36 alpha previously called IL-1F6 and FIL1 epsilon (family of IL-1 member epsilon), is a member of the IL-1 family which includes IL-1b, IL-1a, IL-1ra, IL-18, IL-36ra (IL1F5), IL-36b (IL1F8), IL-36g (IL1F9), IL-37 (IL1F7) and IL-38 (IL-1F10). IL36a is a pro-inflammatory cytokine which plays an important role in innate and adaptive immunity. IL36a is expressed in the immune system and the fetal brain, but not in other tissues or multiple hematopoietic cell lines.IL-36 alpha, beta, and gamma all activate NF-kappa B and MAPK pathways in an IL?1 Rrp2 dependent manner, and induce production of inflammatory cytokines and chemokines such as CXCL8/IL-8. IL-36 alpha and other family members are overexpressed in psoriatic skin lesions, and transgenic overexpression of IL?36 alpha in skin keratinocytes produces epidermal hyperplasia.
Product Categories/Family for IL36alpha recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
17,684 Da
NCBI Official Full Name
interleukin-36 alpha
NCBI Official Synonym Full Names
interleukin 36, alpha
NCBI Official Symbol
IL36A
NCBI Official Synonym Symbols
FIL1; FIL1E; IL1F6; IL-1F6; IL1(EPSILON); FIL1(EPSILON)
NCBI Protein Information
interleukin-36 alpha; FIL1 epsilon; IL-1 epsilon; IL-1F6 (FIL-1-epsilon); interleukin 1 family, member 6 (epsilon); interleukin 1, epsilon; interleukin-1 epsilon; interleukin-1 family member 6
UniProt Protein Name
Interleukin-36 alpha
UniProt Gene Name
IL36A
UniProt Synonym Gene Names
FIL1E; IL1E; IL1F6; IL-1 epsilon; IL-1F6
UniProt Entry Name
IL36A_HUMAN
Uniprot Description
IL1F6: Belongs to the IL-1 family.
Protein type: Cytokine
Chromosomal Location of Human Ortholog: 2q12-q14.1
Cellular Component: extracellular space; extracellular region
Molecular Function: interleukin-1 receptor binding; cytokine activity
Biological Process: cytokine and chemokine mediated signaling pathway; positive regulation of interleukin-6 production; innate immune response; immune response; inflammatory response
Research Articles on IL36alpha
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Product Notes
The IL36alpha il36a (Catalog #AAA9719052) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 153aa. The amino acid sequence is listed below: Lys6-Phe15 8. It is sometimes possible for the material contained within the vial of "IL36 alpha, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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