IL-2 Receptor Subunit Beta/IL-2RB/CD122 Recombinant Protein | IL-2 recombinant protein

Recombinant Mouse IL-2 Receptor Subunit Beta/IL-2RB/CD122 (C-6His)

Cat. Num. AAA2569365

• Gene Names: Il2rb; p70; CD122; IL15Rbeta; Il-2Rbeta; IL-15Rbeta; Il-2/15Rbeta
• Purity: >90% as determined by reducing SDS-PAGE
• Synonyms: IL-2 Receptor Subunit Beta/IL-2RB/CD122; Recombinant Mouse IL-2 Receptor Subunit Beta/IL-2RB/CD122 (C-6His); Interleukin-2 receptor subunit beta; IL2RB; IL-2 receptor subunit beta; IL-2R subunit beta; High affinity IL-2 receptor subunit beta; CD122; IL-2 recombinant protein

• Host: Human Cells
• Purity/Purification: >90% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from a 0.2um filtered solution of PBS, pH7.4.
• Sequence: Ala27-Glu240

• Species: Mouse
• Tag: C-6His
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Recombinant Mouse Interleukin-2 Receptor subunit beta is produced by our Mammalian expression system and the target gene encoding Ala27-Glu240 is expressed with a 6His tag at the C-terminus.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

SDS-Page

Related Product Information for IL-2 recombinant protein

IL-2RB, also known asinterleukin-2 receptor subunit beta,is the receptor for interleukin-2. IL2 receptor complex is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. IL2 receptor complex has three forms with respect to ability to bind IL2. IL-2RB is belonged to a type I membrane protein,and has a 26 residue signal peptide, a 214 residue extracellular region, a 25 residue transmembrane region and a 286 residue cytoplasmic domain. IL-2RB is the subunit critical for receptor-mediated signaling via physically or functionally coupling to other signaling molecules, such as the Jak-STAT and Src-family protein tyrosine kinase although it lacks apparent catalytic motifs.

NCBI and Uniprot Product Information

• NCBI GI #: 6680427
• NCBI GeneID: 16185
• NCBI Accession #: NP_032394.1
• NCBI GenBank Nucleotide #: NM_008368.4
• UniProt Accession #: P16297; Q3TZT2
• Molecular Weight: 60,539 Da
• NCBI Official Full Name: interleukin-2 receptor subunit beta
• NCBI Official Synonym Full Names: interleukin 2 receptor, beta chain
• NCBI Official Symbol: Il2rb
• NCBI Official Synonym Symbols: p70; CD122; IL15Rbeta; Il-2Rbeta; IL-15Rbeta; Il-2/15Rbeta
• NCBI Protein Information: interleukin-2 receptor subunit beta
• UniProt Protein Name: Interleukin-2 receptor subunit beta
• UniProt Gene Name: Il2rb
• UniProt Synonym Gene Names: IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB
• UniProt Entry Name: IL2RB_MOUSE

NCBI Description

The interleukin 2 receptor is composed of alpha and beta subunits. The beta subunit encoded by this gene is very homologous to the human beta subunit and also shows structural similarity to other cytokine receptors. [provided by RefSeq, Jul 2008]

Uniprot Description

IL2RB: Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I. Belongs to the type I cytokine receptor family. Type 4 subfamily.

Protein type: Receptor, cytokine; Membrane protein, integral

Cellular Component: cell surface; external side of plasma membrane; integral to membrane; membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-2 binding; interleukin-2 receptor activity

Biological Process: cytokine and chemokine mediated signaling pathway; natural killer cell activation; negative regulation of apoptosis