Typical Testing Data/Standard Curve (for reference only)
Human Interleukin-2 receptor subunit alpha ELISA Kit | IL2RA elisa kit
Human Interleukin-2 receptor subunit alpha ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
NCBI Description
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]
Uniprot Description
IL2RA: Receptor for interleukin-2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 10p15-p14
Cellular Component: external side of plasma membrane; integral to membrane; intracellular; plasma membrane
Molecular Function: drug binding; interleukin-2 binding; interleukin-2 receptor activity
Biological Process: activated T cell apoptosis; activation of MAPKK activity; apoptosis; axon guidance; cell proliferation; cell surface receptor linked signal transduction; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; immune response; inflammatory response; inflammatory response to antigenic stimulus; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; negative regulation of defense response to virus; negative regulation of immune response; negative regulation of inflammatory response; negative regulation of T cell proliferation; nerve growth factor receptor signaling pathway; Notch signaling pathway; positive regulation of activated T cell proliferation; positive regulation of T cell differentiation; Ras protein signal transduction; regulation of T cell homeostatic proliferation; regulation of T cell tolerance induction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway
Disease: Diabetes Mellitus, Insulin-dependent, 10; Interleukin 2 Receptor, Alpha, Deficiency Of
Research Articles on IL2RA
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Product Notes
The Human IL2RA il2ra (Catalog #AAA2884496) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2884496 ELISA Kit recognizes Human IL2RA. It is sometimes possible for the material contained within the vial of "Interleukin-2 receptor subunit alpha, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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