IL-1 receptor 1 (CD121a) Recombinant Protein | CD121a recombinant protein
Human IL-1 receptor 1 Recombinant (CD121a)
Avoid repeated freeze/thaw cycles.
• role of toll interleukin-1 receptor (IL-1R) 8, a negative regulator of IL-1R/toll-like receptor signaling, in resistance to acute pseudomonas aeruginosa lung infection .Infect. Immun., Jan 2012; 80: 100 - 109.
• IL-1R–associated kinase-1 mediates protein kinase c-induced il-1β production in monocytes .J. Immunol., Sep 2011; 187: 2632 - 2645.
• effect of mitomycin c on IL-1R expression, il-1–related hepatocyte growth factor secretion and corneal epithelial cell migration .Invest. Ophthalmol. Vis. Sci., Mar 2010; 51: 1389 - 1396.
• mycobacterium bovis bacillus calmette-guérin vaccination mobilizes innate myeloid-derived suppressor cells restraining in vivo t cell priming via IL-1R–dependent nitric oxide production .J. Immunol., Feb 2010; 184: 2038 - 2047.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]
Uniprot Description
IL-1RA: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Belongs to the interleukin-1 receptor family.
Protein type: Membrane protein, integral; Receptor, cytokine; EC 2.7.11.25
Chromosomal Location of Human Ortholog: 2q12
Cellular Component: cell surface; membrane; integral to plasma membrane; plasma membrane; extracellular region
Molecular Function: interleukin-1, Type I, activating receptor activity; signal transducer activity; protein binding; transmembrane receptor activity; protease binding; platelet-derived growth factor receptor binding; interleukin-1 receptor activity
Biological Process: cell surface receptor linked signal transduction; regulation of inflammatory response; immune response
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Product Notes
The CD121a il1r1 (Catalog #AAA553050) is a Recombinant Protein produced from HEk293 Cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "IL-1 receptor 1 (CD121a), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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