IL18BP recombinant protein

Recombinant Human IL18BP Protein

Cat. Num. AAA8249250

• Gene Names: IL18BP; IL18BPa
• Reactivity: Human
• Applications: ELISA, Western Blot, SDS-Page
• Purity: Greater than 95% as determined by reducing SDS-PAGE.
• Synonyms: IL18BP; Recombinant Human IL18BP Protein; Interleukin-18-binding protein; IL-18BP; Tadekinig-alfa; IL18BP recombinant protein

• Host: Human cells
• Reactivity: Human
• Purity/Purification: Greater than 95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 muM filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
• Sequence: TPVSQTTTAA TASVRSTKDP CPSQPPVFPA AKQCPALEVT WPEVEVPLNG TLSLSCVACS RFPNFSILYW LGNGSFIEHL PGRLWEGSTS RERGSTGTQL CKALVLEQLT PALHSTNFSC VLVDPEQVVQ RHVVLAQLWA GLRATLPPTQ EALPSSHSSP QQQGVDDIEG RMDEPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSREEMTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGK
• Sequence Length: 194

• Applicable Applications for IL18BP recombinant protein: ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)
• Endotoxin: Less than 0.1 ng/mug (1 IEU/mug) as determined by LAL test.
• Directions for Use: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 mug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Preparation and Storage: Lyophilized protein should be stored at -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at -20 degree C for 3 months.

Related Product Information for IL18BP recombinant protein

Recombinant Human IL18BP Protein is produced by our mammalian expression system and the target gene encoding Thr31-Gly194 is expressed with a Fc tag at the C-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 89111125
• NCBI GeneID: 10068
• NCBI Accession #: NP_001034748.1
• NCBI GenBank Nucleotide #: NM_001039659.1
• UniProt Accession #: O95998; O95993; O96027; Q9NZA9; Q9UBR7; B3KUZ0; B7WPK4
• Molecular Weight: 17,478 Da
• NCBI Official Full Name: interleukin-18-binding protein isoform a
• NCBI Official Synonym Full Names: interleukin 18 binding protein
• NCBI Official Symbol: IL18BP
• NCBI Official Synonym Symbols: IL18BPa
• NCBI Protein Information: interleukin-18-binding protein
• UniProt Protein Name: Interleukin-18-binding protein
• Protein Family: Interleukin-18-binding protein
• UniProt Gene Name: IL18BP
• UniProt Synonym Gene Names: IL-18BP
• UniProt Entry Name: I18BP_HUMAN

NCBI Description

The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

Uniprot Description

IL18BP: Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: extracellular region; extracellular space

Molecular Function: interleukin-18 binding; receptor antagonist activity

Biological Process: T-helper 1 type immune response