IL18 recombinant protein

Recombinant Mouse IL18 Protein

Cat. Num. AAA8249249

• Gene Names: Il18; Igif; Il-18
• Reactivity: Mouse
• Applications: Western Blot, SDS-Page
• Purity: Greater than 95% as determined by reducing SDS-PAGE.
• Synonyms: IL18; Recombinant Mouse IL18 Protein; IGIF; IL1F4; Interleukin-18; IL-18; Iboctadekin; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma; IL18 recombinant protein

• Reactivity: Mouse
• Purity/Purification: Greater than 95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 uM filtered solution of PBS, pH 7.4.
• Sequence: MNHKVHHHHH HMNFGRLHCT TAVIRNINDQ VLFVDKRQPV FEDMTDIDQS ASEPQTRLII YMYKDSEVRG LAVTLSVKDS KMSTLSCKNK IISFEEMDPP ENIDDIQSDL IFFQKRVPGH NKMEFESSLY EGHFLACQKE DDAFKLILKK KDENGDKSVM FTLTNLHQS
• Sequence Length: 192

• Applicable Applications for IL18 recombinant protein: E, WB, SDS=PAGE, MS
• Source: E.Coli
• Quality Control: Endotoxin: Less than 0.1 Ug/Ug (1 IEU/Ug) as determined by LAL test.
• Directions for Use: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 mug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Preparation and Storage: Lyophilized protein should be stored at -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at -20°C for 3 months.

Related Product Information for IL18 recombinant protein

Recombinant Mouse IL18 Protein is produced by our E. coli expression system and the target gene encoding Asn36-Ser192 is expressed with a 6His tag at the N-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 6680413
• NCBI GeneID: 16173
• NCBI Accession #: NP_032386.1
• NCBI GenBank Nucleotide #: NM_008360.1
• UniProt Accession #: P70380
• NCBI Official Full Name: interleukin-18
• NCBI Official Synonym Full Names: interleukin 18
• NCBI Official Symbol: Il18
• NCBI Official Synonym Symbols: Igif; Il-18
• NCBI Protein Information: interleukin-18
• UniProt Protein Name: Interleukin-18
• Protein Family: Interleukin
• UniProt Gene Name: Il18
• UniProt Synonym Gene Names: Igif; IL-18; IFN-gamma-inducing factor; IL-1 gamma
• UniProt Entry Name: IL18_MOUSE

Uniprot Description

IL18: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. Belongs to the IL-1 family.

Protein type: Cytokine

Cellular Component: apical plasma membrane; cytoplasm; extracellular space

Molecular Function: cytokine activity

Biological Process: activation of protein kinase B; angiogenesis; cholesterol homeostasis; detection of mechanical stimulus involved in sensory perception of pain; immune response; induction of apoptosis via death domain receptors; inflammatory response; interferon-gamma biosynthetic process; interleukin-13 biosynthetic process; lipopolysaccharide-mediated signaling pathway; MAPKKK cascade; natural killer cell activation; negative regulation of myoblast differentiation; negative regulation of neutrophil apoptosis; negative regulation of peptidyl-tyrosine phosphorylation; positive regulation of activated T cell proliferation; positive regulation of apoptosis; positive regulation of chemokine production; positive regulation of collagen biosynthetic process; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of interferon-gamma production; positive regulation of interleukin-17 production; positive regulation of interleukin-8 production; positive regulation of natural killer cell proliferation; positive regulation of neuron apoptosis; positive regulation of NF-kappaB import into nucleus; positive regulation of NK T cell proliferation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of superoxide release; positive regulation of T-helper 2 cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of vascular permeability; regulation of cell adhesion; response to hypoxia; sleep; T-helper 1 type immune response