IL7-RA/CD127 recombinant protein

Recombinant Human IL7-RA/CD127 Protein (C-His)

Cat. Num. AAA2557238

• Gene Names: IL17RA; CD217; IL17R; IMD51; CANDF5; CDw217; IL-17RA; hIL-17R
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: IL7-RA/CD127; Recombinant Human IL7-RA/CD127 Protein (C-His); CD127; CDW127; IL-17R; IL-17R-alpha; IL7RA; ILRA; IL-17RA; IL-17 R alpha; Interleukin-17 receptor A; IL7-RA/CD127 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, PH7.0.
• Sequence: Leu33-Trp320
• Sequence Length: 866

• Species: Human
• Endotoxin: < 1.0 EU per mug as determined by the LAL method.
• Fusion Tag: C-His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for IL7-RA/CD127 recombinant protein

Protein Construction: Recombinant Human IL7-RA is produced by our mammalian expression system and the target gene encoding Leu33-Trp320 is expressed with a 6His tag at the C-terminus.

Background: CD38, also called ADP-ribosyl cyclase, is a Type II integral membrane protein with 301 amino acids in length that belongs to the ADP-ribosyl cyclase family. It synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. And also moonlights as a receptor in cells of the immune system. CD38 is expressed in B and T lymphocytes, osteoclasts, and in cardiac, pancreatic, liver and kidney cells. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in many types of cells, including neutrophils and pancreatic beta cells.

NCBI and Uniprot Product Information

• NCBI GI #: 23238208
• NCBI GeneID: 23765
• NCBI Accession #: NP_055154.3
• NCBI GenBank Nucleotide #: NP_055154.3
• UniProt Accession #: Q96F46
• Molecular Weight: Molecular Mass: 34.5kDa; Actual Protein Molecular Mass: 50-80kDa
• NCBI Official Full Name: interleukin-17 receptor A isoform 1
• NCBI Official Synonym Full Names: interleukin 17 receptor A
• NCBI Official Symbol: IL17RA
• NCBI Official Synonym Symbols: CD217; IL17R; IMD51; CANDF5; CDw217; IL-17RA; hIL-17R
• NCBI Protein Information: interleukin-17 receptor A
• UniProt Protein Name: Interleukin-17 receptor A
• UniProt Gene Name: IL17RA
• UniProt Synonym Gene Names: IL17R; IL-17 receptor A; IL-17RA
• UniProt Entry Name: I17RA_HUMAN

NCBI Description

Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]

Uniprot Description

IL17RA: Receptor for IL17A and IL17F. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling. Widely expressed.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 22q11.1

Cellular Component: integral to plasma membrane; extracellular region

Molecular Function: protein binding; interleukin-17 receptor activity

Biological Process: cell surface receptor linked signal transduction; positive regulation of interleukin-23 production; cytokine and chemokine mediated signaling pathway

Disease: Candidiasis, Familial, 5