Interleukin-17 A/F Heterodimer Recombinant Protein | IL 17 A/F recombinant protein

Recombinant Human Interleukin-17 A/F Heterodimer

Cat. Num. AAA143516

• Gene Names: Il17f; C87042; IL-17F
• Purity: Greater than 98.0% as determined by SDS-PAGE.
• Synonyms: Interleukin-17 A/F Heterodimer; Recombinant Human Interleukin-17 A/F Heterodimer; IL 17A/F Human; Interleukin-17A/F Heterodimer Human Recombinant; IL17A/F; IL17 A/F; IL-17A/F; IL-17 A/F; IL17AF; IL-17 AF; Interleukin-17 A/F; Interleukin-17 AF; IL 17 A/F recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 98.0% as determined by SDS-PAGE.
• Form/Format: Lyophilized from a concentrated (1mg/ml) solution containing no additives.; Sterile Filtered White lyophilized (freeze-dried) powder.
• Sequence: MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA.MRKIPKVGHT FFQKPESCPP VPGGSMKLDI GIINENQRVS MSRNIESRST SPWNYTVTWD PNRYPSEVVQ AQCRNLGCIN AQGKEDISMN SVPIQQETLV VRRKHQGCSV SFQLEKVLVT VGCTCVTPVI HHVQ
• Sequence Length: 161

• Solubility: It is recommended to reconstitute the lyophilized Human IL-17A/F in sterile water not more than 1mg/ml, which can then be further diluted to other aqueous solutions.
• Preparation and Storage: Lyophilized Human IL-17A/F although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Human IL-17A/F should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Related Product Information for IL 17 A/F recombinant protein

Description: IL-17A/F Human Recombinant produced in E Coli is a heterodimeric, non-glycosylated polypeptide chain containing 1 monomeric subunit of each IL-17A & IL-17F. The active dimer contains 271 amino acids and having a total molecular mass of 30.7 kDa. The IL-17A/F Human is purified by proprietary chromatographic techniques.

Introduction: Human IL-17A/F is a 40kDa glycoprotein which is secreted as a disulfide-linked heterodimer. IL-17A/F consists of two proteins of the IL-17 family, IL-17A and IL17F. Proteins of the 6 homodimeric IL17 family show a cysteine knot motif that contains two disulfide-bonds. Human IL17A is produced as a 155 a.a precursor that includes a 23 amino acids signal sequence and a 132 amino acid chain that includes an N-linked glycosylation site. Human IL17F is produced as a 153 amino acid precursor with a 20 amino acid signal sequence and a 133 amino acid region. Similar to IL17A, IL17F also has an N-linked glycosylation site. Both proteins (IL17A & IL17F) share 50% amino acid sequence identity. Human IL17A & IL17F show approximately 60% homology in their amino acid sequence to mouse IL-17A and IL-17F. Interleukin-17A/F and IL17A, IL17F homodimers are manufactured by activted CD4+ T cells, called Th17. IL-23 causes Th17 lymphocytes to manufacture IL-17A/F. IL17RA and IL17RC form a heterodimer for the binding of IL17A and IL17F. IL-17A/F binds IL-17RA. Interleukin-17A/F induces chemokine production and airway neutrophilia with intermediate potency between IL17A (most potent) and IL17F (least potent).

Product Categories/Family for IL 17 A/F recombinant protein

Cytokines and Growth Factors; Cytokines; Interleukin

NCBI and Uniprot Product Information

• NCBI GI #: 119360346
• NCBI GeneID: 257630
• NCBI Accession #: NP_665855.2
• NCBI GenBank Nucleotide #: NM_145856.2
• Molecular Weight: 17,020 Da
• NCBI Official Full Name: interleukin-17F
• NCBI Official Synonym Full Names: interleukin 17F
• NCBI Official Symbol: Il17f
• NCBI Official Synonym Symbols: C87042; IL-17F
• NCBI Protein Information: interleukin-17F
• UniProt Protein Name: Interleukin-17F
• UniProt Gene Name: Il17f
• UniProt Synonym Gene Names: IL-17F
• UniProt Entry Name: IL17F_MOUSE

Uniprot Description

IL17F: Stimulates the production of other cytokines such as IL- 6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6). CANDF6 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. Belongs to the IL-17 family.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region

Molecular Function: protein homodimerization activity; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; cytokine binding; cytokine activity

Biological Process: proteoglycan metabolic process; negative regulation of angiogenesis; regulation of transforming growth factor beta receptor signaling pathway; regulation of interleukin-8 biosynthetic process; regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; cartilage development; cytokine biosynthetic process; lymphotoxin A biosynthetic process; regulation of interleukin-2 biosynthetic process; regulation of interleukin-6 biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; inflammatory response