Human interleukin 17C ELISA Kit | IL17C elisa kit

Human Interleukin17C, IL17C ELISA Kit

Cat. Num. AAA705684

• Gene Names: IL17C; CX2; IL-17C
• Reactivity: Human
• Synonyms: interleukin 17C; Human Interleukin17C; IL17C ELISA Kit; Human Interleukin17C (IL17C) ELISA Kit; CX2; IL-17C; IL-21; MGC126884; MGC138401; cytokine CX2; IL17C elisa kit

• Reactivity: Human
• Specificity: This assay has high sensitivity and excellent specificity for detection of Human IL17C. No significant cross-reactivity or interference between Human IL17C and analogues was observed.
• Sequence Length: 197

• Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%; Three samples of known concentration were tested twenty times on one plate to assess.; Inter-assay Precision (Precision between assays): CV% is less than 10%; Three samples of known concentration were tested in twenty assays to assess.
• Detection Wavelength: 450 nm
• Sample Volume: 50-100ul
• Preparation and Storage: Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for IL17C elisa kit

Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to IL17C. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific for IL17C and Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB (3,3',5,5' tetramethyl-benzidine) substrate solution is added to each well. Only those wells that contain IL17C, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The concentration of IL17C in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 7019435
• NCBI GeneID: 27189
• NCBI Accession #: NP_037410.1
• NCBI GenBank Nucleotide #: NM_013278.3
• UniProt Accession #: Q9P0M4; Q3MIG8; Q9HC75
• Molecular Weight: 21,765 Da
• NCBI Official Full Name: interleukin-17C
• NCBI Official Synonym Full Names: interleukin 17C
• NCBI Official Symbol: IL17C
• NCBI Official Synonym Symbols: CX2; IL-17C
• NCBI Protein Information: interleukin-17C; cytokine CX2
• UniProt Protein Name: Interleukin-17C
• Protein Family: Interleukin
• UniProt Gene Name: IL17C
• UniProt Synonym Gene Names: UNQ561/PRO1122; IL-17C
• UniProt Entry Name: IL17C_HUMAN

NCBI Description

The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.1 PublicationManual assertion based on experiment in:Ref.6