IL-13RA/IL-13R recombinant protein

Recombinant Mouse IL-13RA/IL-13R Protein (C-Fc)

Cat. Num. AAA2557486

• Gene Names: Il13ra1; NR4; Il13ra; CD213a1; AI882074; IL-13r[a]; IL-13R-alpha-1
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: IL-13RA/IL-13R; Recombinant Mouse IL-13RA/IL-13R Protein (C-Fc); Interleukin-13 receptor subunit alpha-1; IL-13RA1; Interleukin-13-binding protein; Novel cytokine receptor 4; NR4; CD213a1; IL-13 R alpha 1; IL-13RA/IL-13R recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH7.4.
• Sequence: Ala25-Thr340
• Sequence Length: 424

• Species: Mouse
• Endotoxin: < 1.0 EU per mug as determined by the LAL method.
• Fusion Tag: C-Fc
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for IL-13RA/IL-13R recombinant protein

Protein Construction: Recombinant Mouse IL-13RA is produced by our mammalian expression system and the target gene encoding Ala25-Thr340 is expressed with a Fc tag at the C-terminus.

Background: Interleukin-13 receptor subunit alpha-1(IL-13RA1), also known as NR4, belongs to the hemopoietin receptor family. Interleukin-13 receptor is a complex of IL4R, IL13RA1, and possibly other components. It interacts with TRAF3IP1 and binds with low affinity to interleukin-13(IL3). IL-13RA1, together with IL4RA, can form a functional receptor for IL13. It also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity. The WSXWS motif in domains appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

NCBI and Uniprot Product Information

• NCBI GI #: 40254373
• NCBI GeneID: 16164
• NCBI Accession #: NP_598751.3
• NCBI GenBank Nucleotide #: NP_598751.3
• UniProt Accession #: O09030
• Molecular Weight: Molecular Mass: 63kDa; Actual Protein Molecular Mass: 80-120kDa
• NCBI Official Full Name: interleukin-13 receptor subunit alpha-1
• NCBI Official Synonym Full Names: interleukin 13 receptor, alpha 1
• NCBI Official Symbol: Il13ra1
• NCBI Official Synonym Symbols: NR4; Il13ra; CD213a1; AI882074; IL-13r[a]; IL-13R-alpha-1
• NCBI Protein Information: interleukin-13 receptor subunit alpha-1
• UniProt Protein Name: Interleukin-13 receptor subunit alpha-1
• UniProt Gene Name: Il13ra1
• UniProt Synonym Gene Names: Il13r; Il13ra; IL-13 receptor subunit alpha-1; IL-13R subunit alpha-1; IL-13R-alpha-1; IL-13RA1; NR4
• UniProt Entry Name: I13R1_MOUSE

NCBI Description

This gene encodes a transmembrane protein that complexes with interleukin 4 receptor alpha (IL4RA) to form a functional receptor for interleukin-13. Signalling through this pathway mediates allergy response and occurs during bronchial asthma. [provided by RefSeq, May 2015]

Uniprot Description

IL13R: Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity. Belongs to the type I cytokine receptor family. Type 5 subfamily.

Protein type: Receptor, cytokine; Membrane protein, integral

Cellular Component: membrane; integral to membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-13 receptor activity