Interleukin-11 Recombinant Protein | IL-11 recombinant protein
Human Interleukin-11 Recombinant
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Recombinant IL-11 is a disulfide-linked monomer protein consisting of 180 amino acid residue subunits, and migrates as an approximately 19 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE.
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.
Avoid repeated freeze/thaw cycles.
• il-17f-induced IL-11 release in bronchial epithelial cells via msk1-creb pathway .Am J Physiol Lung Cell Mol Physiol, May 2009; 296: L804 - L810.
• endogenous IL-11 signaling is essential in th2- and il-13–induced inflammation and mucus production .Am. J. Respir. Cell Mol. Biol., Dec 2008; 39: 739 - 746.
• decreased mapk- and pge2-dependent IL-11 production in gi2–/– colonic myofibroblasts .Am J Physiol Gastrointest Liver Physiol, Jun 2007; 292: G1511 - G1519.
• interferon- downregulates il-1 and tnf- induced IL-11 secretion by human retinal pigment epithelial cells .Invest. Ophthalmol. Vis. Sci., May 2007; 48: 2524.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
Uniprot Description
IL11: Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Belongs to the IL-6 superfamily.
Protein type: Motility/polarity/chemotaxis; Cytokine; Cell cycle regulation; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19q13.3-q13.4
Cellular Component: extracellular space; cytoplasm; extracellular region
Molecular Function: growth factor activity; cytokine activity; interleukin-11 receptor binding
Biological Process: fat cell differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of MAPKKK cascade; cell-cell signaling; megakaryocyte differentiation; negative regulation of hormone secretion; B cell differentiation; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of peptidyl-serine phosphorylation
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Product Notes
The IL-11 il11 (Catalog #AAA553023) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MNCVCRLVLV VLSLWPDTAV APGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL. It is sometimes possible for the material contained within the vial of "Interleukin-11, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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