IL-10 Receptor Subunit beta/IL-10RB Recombinant Protein | IL-10RB recombinant protein

Recombinant Human IL-10 Receptor Subunit beta/IL-10RB Protein (C-Fc)

Cat. Num. AAA2552788

• Gene Names: IL10RB; CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: IL-10 Receptor Subunit beta/IL-10RB; Recombinant Human IL-10 Receptor Subunit beta/IL-10RB Protein (C-Fc); Interleukin-10 receptor subunit beta(IL10RB); Cytokine receptor class-II member 4; Cytokine receptor family 2 member 4; Interleukin-10 receptor subunit 2; IL-10RB recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH 7.4.
• Sequence Positions: Met20-Ser220
• Sequence Length: 325

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: C-Fc
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for IL-10RB recombinant protein

Interleukin-10 receptor subunit beta(IL10RB), also known as Cytokine receptor class-II member 4, Cytokine receptor family 2 member 4, Interleukin-10 receptor subunit 2, belongs to the type II cytokine receptor family. IL10RB is a single- pass type I membrane protein and contains two fibronectin type-III domains. It is an accessory chain which is essential for the active interleukin 10 receptor complex. Coexpression of IL10RB and IL10RA proteins has been shown to be required for IL10-induced signal transduction. Defects in IL10RB are the cause of inflammatory bowel disease type 25 (IBD25) which is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology.

NCBI and Uniprot Product Information

• NCBI GI #: 24430215
• NCBI GeneID: 3588
• NCBI Accession #: NP_000619.3
• NCBI GenBank Nucleotide #: NM_000628.4
• UniProt Accession #: Q08334; Q9BUU4
• Molecular Weight: Molecular Mass: 50.6 kDa; Actual Protein Molecular Mass: 65-90 kDa
• NCBI Official Full Name: interleukin-10 receptor subunit beta
• NCBI Official Synonym Full Names: interleukin 10 receptor subunit beta
• NCBI Official Symbol: IL10RB
• NCBI Official Synonym Symbols: CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2
• NCBI Protein Information: interleukin-10 receptor subunit beta
• UniProt Protein Name: Interleukin-10 receptor subunit beta
• UniProt Gene Name: IL10RB
• UniProt Synonym Gene Names: CRFB4; D21S58; D21S66; IL-10 receptor subunit beta; IL-10R subunit beta; IL-10RB; CRF2-4; IL-10R subunit 2; IL-10R2

NCBI Description

The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]

Uniprot Description

Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.