SDS-PAGE
IL10RB / IL10R2 recombinant protein
Recombinant Mouse IL10RB / IL10R2 Protein (Fc tag)
Gene Names
Il10rb; Crfb4; CRF2-4; Il10r2; D21S58h; IL-10R2; AI528744; D16H21S58; 6620401D04Rik
Purity
> 92 % as determined by SDS-PAGE
Synonyms
IL10RB / IL10R2; Recombinant Mouse IL10RB / IL10R2 Protein (Fc tag); 6620401D04Rik; AI528744; CRF2-4; Crfb4; D16H21S58; D21S58h; IL-10R2; Il10r2; IL10RB / IL10R2 recombinant protein
Host
Human Cells
Purity/Purification
> 92 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
351
Application Notes
The secreted recombinant mouse IL10RB Fc is a disulfide-linked homodimer. The reduced monomer comprises comprises 442 amino acids and has a calculated molecular mass of 50.5 kDa. As a result of glycosylation, the apparent molecular mass of rm IL10RB/Fc monomer is approximately 65-75 kDa in SDS-PAGE under reducing conditions.
Predicted N Terminal
Met 22
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
SDS-PAGE
Related Product Information for IL10RB / IL10R2 recombinant protein
Background: Interleukin 10 receptor, beta subunit (IL10RB/IL-10RB) also known as Cytokine receptor family 2 member 4, Interleukin-10 receptor subunit 2, and cytokine receptor family II, member 4, is a subunit for the interleukin-10 receptor. IL10RB/IL-10RB belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. Defects in IL10RB/IL-10RB are the cause of inflammatory bowel disease type 25 (IBD25). It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotype s. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
Description: A DNA sequence encoding the extracellular domain of mouse IL10RB (NP_032375.2) (Met 1-Ser 222) was fused with the Fc region of human IgG1 at the C-terminus.
Description: A DNA sequence encoding the extracellular domain of mouse IL10RB (NP_032375.2) (Met 1-Ser 222) was fused with the Fc region of human IgG1 at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
39,774 Da
NCBI Official Full Name
interleukin-10 receptor subunit beta
NCBI Official Synonym Full Names
interleukin 10 receptor, beta
NCBI Official Symbol
Il10rb
NCBI Official Synonym Symbols
Crfb4; CRF2-4; Il10r2; D21S58h; IL-10R2; AI528744; D16H21S58; 6620401D04Rik
NCBI Protein Information
interleukin-10 receptor subunit beta
UniProt Protein Name
Interleukin-10 receptor subunit beta
UniProt Gene Name
Il10rb
UniProt Synonym Gene Names
Crfb4; IL-10 receptor subunit beta; IL-10R subunit beta; IL-10RB; CRF2-4; IL-10R subunit 2; IL-10R2
Uniprot Description
IL10RB: Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IL29. Defects in IL10RB are the cause of inflammatory bowel disease type 25 (IBD25). It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Belongs to the type II cytokine receptor family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 16 C3.3|16 52.87 cM
Cellular Component: integral to membrane; plasma membrane
Molecular Function: interleukin-10 receptor activity; protein binding
Research Articles on IL10RB / IL10R2
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Product Notes
The IL10RB / IL10R2 il10rb (Catalog #AAA2546761) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The secreted recombinant mouse IL10RB Fc is a disulfide-linked homodimer. The reduced monomer comprises comprises 442 amino acids and has a calculated molecular mass of 50.5 kDa. As a result of glycosylation, the apparent molecular mass of rm IL10RB/Fc monomer is approximately 65-75 kDa in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the IL10RB / IL10R2 il10rb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL10RB / IL10R2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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