NCBI and Uniprot Product Information
NCBI Description
Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]
Uniprot Description
IL34: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Belongs to the IL-34 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Cytokine; Secreted, signal peptide; Cell cycle regulation
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: extracellular space
Molecular Function: growth factor activity; cytokine activity; macrophage colony stimulating factor receptor binding
Biological Process: positive regulation of cell proliferation; innate immune response; positive regulation of protein amino acid phosphorylation; inflammatory response
Research Articles on Il-34
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Product Notes
The Rabbit Il-34 il34 (Catalog #AAA724164) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA724164 ELISA Kit recognizes Rabbit Il-34. It is sometimes possible for the material contained within the vial of "Interleukin 34, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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