IL-18 receptor 1 Recombinant Protein | IL-18R recombinant protein
Mouse IL-18 receptor 1 Recombinant
Purity
>98%, as determined by SDS-PAGE and HPLC
Synonyms
IL-18 receptor 1; Mouse IL-18 receptor 1 Recombinant; Mouse IL-18 receptor alpha Recombinant; il-18ra1; il18RA; interleukin-18 r; cd218a; IL-18R recombinant protein
Host
HEk293 Cells
Purity/Purification
>98%, as determined by SDS-PAGE and HPLC
Form/Format
Recombinant Mouse Interleukin-18 receptor alpha is supplied as lyophilized 0.2 um filtered PBS solution, pH7.2.
Host Note
Optimized DNA sequence encoding extracellular domain of Mouse IL-18 receptor including a C terminal His tag was expressed in HEK293 cells.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Molecular Weight Note
Recombinant mouse IL-18 receptor alpha is a monomer protein consisting of 318 amino acid residue subunits, due to glycosylation migrates as an approximately 65kD protein under reducing SDS-PAGE conditions.
Preparation and Storage
Recombinant Mouse IL-18 receptor alpha, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months.
Avoid repeated freeze/thaw cycles.
Avoid repeated freeze/thaw cycles.
Related Product Information for IL-18R recombinant protein
The IL-18R complex is composed of two known chains, IL-18 receptor α chain (IL-18Rα) and IL-18Rβ. IL-18Rα (IL-1R5) was originally described as IL-1 receptor-related protein (IL-1Rrp) because of its homology with the IL-1/Toll receptor family and is the extracellular binding domain of the IL-18R complex. IL- 18Rβ (also known as IL- 18RAcPL or IL-1R7) is the signal transducing chain of the IL-18R complex and is also a member of the IL-1R family. It has been widely believed that the IL-18Rα is not expressed on naive T cells, but is induced during differentiation of Th1, but not Th2, cells.
Product Categories/Family for IL-18R recombinant protein
References
• the interaction between il-18 and IL-18 receptor limits the magnitude of protective immunity and enhances pathogenic responses following infection with intracellular bacteria .J. Immunol., Aug 2011; 187: 1333 - 1346.
• the natural soluble form of IL-18 receptor β exacerbates collagen-induced arthritis via modulation of t-cell immune responses .Ann Rheum Dis, Jan 2010; 69: 276 - 283.
• il-18 is induced and IL-18 receptor plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation .J. Immunol., Feb 2007; 178: 1948 - 1959.
• responses of il-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor .PNAS, Nov 2006; 103: 16852 - 16857.
• blockade of IL-18 receptor signaling delays the onset of autoimmune disease in mrl-faslpr mice .J. Immunol., Oct 2004; 173: 5312 - 5318.
• the natural soluble form of IL-18 receptor β exacerbates collagen-induced arthritis via modulation of t-cell immune responses .Ann Rheum Dis, Jan 2010; 69: 276 - 283.
• il-18 is induced and IL-18 receptor plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation .J. Immunol., Feb 2007; 178: 1948 - 1959.
• responses of il-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor .PNAS, Nov 2006; 103: 16852 - 16857.
• blockade of IL-18 receptor signaling delays the onset of autoimmune disease in mrl-faslpr mice .J. Immunol., Oct 2004; 173: 5312 - 5318.
NCBI and Uniprot Product Information
UniProt Accession #
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Product Notes
The IL-18R (Catalog #AAA553314) is a Recombinant Protein produced from HEk293 Cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "IL-18 receptor 1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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