Human Insulin-like growth factor-binding protein 2 ELISA Kit | IGFBP2 elisa kit

Human Insulin-like growth factor-binding protein 2 ELISA Kit

Cat. Num. AAA288888

• Gene Names: IGFBP2; IBP2; IGF-BP53
• Reactivity: Human
• Synonyms: Insulin-like growth factor-binding protein 2; Human Insulin-like growth factor-binding protein 2 ELISA Kit; IBP-2; IGF-binding protein 2; IGFBP-2; IGFBP2; BP2; IBP2; IGFBP2 elisa kit

• Reactivity: Human
• Sequence Length: 328

• Assay Type: Sandwich
• Detection Range: 78-5000 pg/mL
• Sensitivity: 32pg/mL
• Intra-Assay CV: <=7.6%
• Inter-Assay CV: <=8.5%
• Recovery: 105%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 55925576
• NCBI GeneID: 3485
• NCBI Accession #: NP_000588.2
• NCBI GenBank Nucleotide #: NM_000597.2
• UniProt Accession #: P18065; Q14619; Q9UCL3
• Molecular Weight: 34,814 Da
• NCBI Official Full Name: insulin-like growth factor-binding protein 2 isoform a
• NCBI Official Synonym Full Names: insulin like growth factor binding protein 2
• NCBI Official Symbol: IGFBP2
• NCBI Official Synonym Symbols: IBP2; IGF-BP53
• NCBI Protein Information: insulin-like growth factor-binding protein 2
• UniProt Protein Name: Insulin-like growth factor-binding protein 2
• Protein Family: Insulin-like growth factor-binding protein
• UniProt Gene Name: IGFBP2
• UniProt Synonym Gene Names: BP2; IBP2; IBP-2; IGF-binding protein 2; IGFBP-2
• UniProt Entry Name: IBP2_HUMAN

NCBI Description

The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]

Uniprot Description

IGFBP2: Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Binds IGF2 more than IGF1.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: apical plasma membrane; cytoplasmic vesicle; extracellular region; extracellular space

Molecular Function: insulin-like growth factor I binding; insulin-like growth factor II binding; protein binding

Biological Process: aging; cellular protein metabolic process; cellular response to hormone stimulus; female pregnancy; positive regulation of activated T cell proliferation; regulation of cell growth; regulation of insulin-like growth factor receptor signaling pathway; response to drug; response to estradiol stimulus; response to glucocorticoid stimulus; response to lithium ion; response to mechanical stimulus; response to nutrient; response to retinoic acid; signal transduction