IGF2R recombinant protein

Recombinant Human IGF2R protein, C-His Tag

Cat. Num. AAA1562949

• Gene Names: IGF2R; MPR1; MPRI; CD222; CIMPR; M6P-R
• Purity: >90% as determined by SDS-PAGE
• Synonyms: IGF2R; Recombinant Human IGF2R protein; C-His Tag; MPRI M6PR Insulin-like growth factor II receptor CI Man-6-P receptor MPR 300 M6PIGF2 receptor Insulin-like growth factor 2 receptor CI-MPR IGF-II receptor 300kDa mannose 6-phosphate receptor M6PIGF2R Cation-independent mannose-6-phosphate receptor IGF2R CD222; IGF2R recombinant protein

• Host: Mammalian cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Tag: C-His Tag
• Species: Homo sapiens (Human)
• Protein Construction: A DNA sequence encoding the Human IGF2R (Met1-Asp1365) was fused with the C-His Tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder or frozen liquid. They are shipped out with dry ice or blue ice unless customers require otherwise.

Product Categories/Family for IGF2R recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 119964726
• NCBI GeneID: 3482
• NCBI Accession #: NP_000867.2
• NCBI GenBank Nucleotide #: NM_000876.2
• UniProt Accession #: P11717; Q7Z7G9; Q96PT5
• Molecular Weight: 274,375 Da
• NCBI Official Full Name: cation-independent mannose-6-phosphate receptor
• NCBI Official Synonym Full Names: insulin-like growth factor 2 receptor
• NCBI Official Symbol: IGF2R
• NCBI Official Synonym Symbols: MPR1; MPRI; CD222; CIMPR; M6P-R
• NCBI Protein Information: cation-independent mannose-6-phosphate receptor; M6PR; CI-MPR; MPR 300; M6P/IGF2R; IGF-II receptor; M6P/IGF2 receptor; CI Man-6-P receptor; 300 kDa mannose 6-phosphate receptor; insulin-like growth factor II receptor; cation-independent mannose-6 phosphat
• UniProt Protein Name: Cation-independent mannose-6-phosphate receptor
• Protein Family: Cation-independent mannose-6-phosphate receptor
• UniProt Gene Name: IGF2R
• UniProt Synonym Gene Names: MPRI; CI Man-6-P receptor; CI-MPR; M6PR; MPR 300; IGF-II receptor; M6P/IGF2R
• UniProt Entry Name: MPRI_HUMAN

NCBI Description

This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. While the related mouse gene shows exclusive expression from the maternal allele, imprinting of the human gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele. [provided by RefSeq, Apr 2013]

Uniprot Description

IGF2R: a multifunctional type I transmembrane protein receptor that binds insulin-like growth factor 2 at the cell surface and mannose-6-phosphate-tagged proteins in the trans-Golgi network. Also known as the cation-independent mannose-6 phosphate (M6P) receptor. Clears IGF2 from the cell surface to attenuate signaling, and transports M6P-tagged lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. M6P-tagged lysosomal enzymes bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Belongs to the MRL1/IGF2R family.

Protein type: Receptor, misc.; Vesicle; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q26

Cellular Component: extracellular space; cell surface; clathrin coat; focal adhesion; lysosomal membrane; integral to plasma membrane; trans-Golgi network; trans-Golgi network transport vesicle; membrane; nuclear envelope lumen; perinuclear region of cytoplasm; endocytic vesicle; late endosome; endosome

Molecular Function: G-protein coupled receptor activity; identical protein binding; mannose binding; protein binding; retinoic acid binding; enzyme binding; transporter activity; G-protein alpha-subunit binding; phosphoprotein binding; receptor activity; glycoprotein binding; insulin-like growth factor II binding; insulin-like growth factor receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; receptor-mediated endocytosis; organ regeneration; response to retinoic acid; insulin-like growth factor receptor signaling pathway; positive regulation of apoptosis; spermatogenesis; signal transduction; liver development; post-embryonic development

Disease: Hepatocellular Carcinoma