Human intraflagellar transport 140 homolog (Chlamydomonas) ELISA Kit | IFT140 elisa kit
Human Intraflagellar transport protein 140 homolog, IFT140 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes one of the subunits of the intraflagellar transport (IFT) complex A. Intraflagellar transport is involved in the genesis, resorption and signaling of primary cilia. The primary cilium is a microtubule-based sensory organelle at the surface of most quiescent mammalian cells, that receives signals from its environment, such as the flow of fluid, light or odors, and transduces those signals to the nucleus. Loss of the corresponding protein in mouse results in renal cystic disease. [provided by RefSeq, Jun 2012]
Uniprot Description
IFT140: Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance. Defects in IFT140 are the cause of Mainzer-Saldino syndrome (MZSDS). MZSDS is a rare autosomal recessive disease characterized by phalangeal cone- shaped epiphyses, chronic renal disease, nearly constant retinal dystrophy, and mild radiographic abnormality of the proximal femur. Occasional features include short stature, cerebellar ataxia, and hepatic fibrosis.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: centrosome; axoneme; photoreceptor connecting cilium
Biological Process: skeletal morphogenesis; retina development in camera-type eye; organelle organization and biogenesis; cilium biogenesis
Disease: Short-rib Thoracic Dysplasia 9 With Or Without Polydactyly
Research Articles on IFT140
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Product Notes
The Human IFT140 ift140 (Catalog #AAA9329617) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9329617 ELISA Kit recognizes Human IFT140. It is sometimes possible for the material contained within the vial of "intraflagellar transport 140 homolog (Chlamydomonas), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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