Interleukin-28 receptor subunit alpha (Il28ra) Recombinant Protein | Il28ra recombinant protein

Recombinant Mouse Interleukin-28 receptor subunit alpha (Il28ra), partial

Cat. Num. AAA1380818

• Gene Names: Ifnlr1; Il28ra; CRF2-12
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Interleukin-28 receptor subunit alpha (Il28ra); Recombinant Mouse Interleukin-28 receptor subunit alpha (Il28ra); partial; Il28ra recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 21-227
• Sequence: RPRLAPPRNV TLFSQNFTVY LTWLPGLGSP PNVTYFVTYQ SYIKTGWRPV EHCAGIKALV CPLMCLKKLN LYSKFKGRVQ AASAHGRSPR VESRYLEYLF DVELAPPTLV LTQMEKILRV NATYQLPPCM PSLELKYQVE FWKEGLGSKT LFPDTPYGQP VQIPLQQGAS RRHCLSARTV YTLIDIKYSQ FSEPSCIFLE APGDKRA
• Sequence Length: 207

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Il28ra recombinant protein

This protein belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.

NCBI and Uniprot Product Information

• NCBI GI #: 225543249
• NCBI GeneID: 242700
• NCBI Accession #: NP_777276.3
• NCBI GenBank Nucleotide #: NM_174851.3
• UniProt Accession #: Q8CGK5; Q6PEV1
• Molecular Weight: 59,976 Da
• NCBI Official Full Name: interferon lambda receptor 1
• NCBI Official Synonym Full Names: interferon lambda receptor 1
• NCBI Official Symbol: Ifnlr1
• NCBI Official Synonym Symbols: Il28ra; CRF2-12
• NCBI Protein Information: interferon lambda receptor 1
• UniProt Protein Name: Interferon lambda receptor 1
• UniProt Gene Name: Ifnlr1
• UniProt Synonym Gene Names: Il28ra; IFN-lambda R1; CRF2-12; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA

Uniprot Description

The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.