IL28RA Blocking Peptide | IFNLR1 blocking peptide

IL28RA Blocking Peptide (C-term)

• Gene Names: IFNLR1; IFNLR; LICR2; IL28RA; CRF2/12; IL-28R1
• Synonyms: IL28RA; IL28RA Blocking Peptide (C-term); Interferon lambda receptor 1; IFN-lambda receptor 1; IFN-lambda-R1; Cytokine receptor class-II member 12; Cytokine receptor family 2 member 12; CRF2-12; Interleukin-28 receptor subunit alpha; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA; Likely interleukin or cytokine receptor 2; LICR2; IFNLR1; IFNLR1 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 500-513 of HUMAN IFNLR1
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 520

• Peptide ID: 100405167
• Cellular Location: Membrane; Single-pass type I membrane protein
• Tissue Location: Widely expressed.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for IFNLR1 blocking peptide

The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.

NCBI and Uniprot Product Information

• NCBI GI #: 25014103
• NCBI GeneID: 163702
• NCBI Accession #: NP_734464.1
• NCBI GenBank Nucleotide #: NM_170743.3
• UniProt Accession #: Q8IU57; Q5VTX5; Q5VTX7; Q5VTX8; Q6ZML8; Q8IV66; Q8IZI7; Q8IZI8
• NCBI Official Full Name: interferon lambda receptor 1 isoform 1
• NCBI Official Synonym Full Names: interferon lambda receptor 1
• NCBI Official Symbol: IFNLR1
• NCBI Official Synonym Symbols: IFNLR; LICR2; IL28RA; CRF2/12; IL-28R1
• NCBI Protein Information: interferon lambda receptor 1
• UniProt Protein Name: Interferon lambda receptor 1
• Protein Family: Interferon lambda receptor
• UniProt Gene Name: IFNLR1
• UniProt Synonym Gene Names: IL28RA; LICR2; IFN-lambda receptor 1; IFN-lambda-R1; CRF2-12; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA; LICR2
• UniProt Entry Name: INLR1_HUMAN

NCBI Description

The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

IL28RA: The IL28RA/IL10RB dimer is a receptor for IL28A, IL28B and IL29. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the type II cytokine receptor family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: interleukin-28 receptor complex; plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding

Biological Process: cytokine and chemokine mediated signaling pathway; defense response to virus; mucosal immune response; regulation of defense response to virus by host