IL28A Recombinant Protein | IFNL2 recombinant protein

IL28A Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8118677

• Gene Names: IFNL2; IL28A; IL-28A
• Purity: >90 % as determined by SDS-PAGE.
• Synonyms: IL28A; IL28A Protein; Human; Recombinant (His Tag); Human IL-28A/IL28A Protein (His Tag); interferon; lambda 2; IL-28A Protein; ZCYTO20 Protein; IFNL2 recombinant protein

• Host: Yeast
• Purity/Purification: >90 % as determined by SDS-PAGE.
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Sequence Positions: 185aa
• Sequence: Val26-Val200

• Species: Human
• Tag: C-His
• Predicted N Terminal: VAL
• Protein Construction: |A DNA sequence encoding the human IFNL2 (NP_742150.1) (Val26-Val200) was expressed with a polyhistidine tag at the C-terminus
• Activity: Measured in antiviral assays using HepG2 cells infected with vesicular stomatitis virus. The ED50 for this effect is 1.7-6.8ug/mL.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; Shipping: They are shipped out with blue ice pack

Testing Data

Testing Data

(Measured in antiviral assays using HepG2 cells infected with vesicular stomatitis virus. The ED50 for this effect is 1.7-6.8 ug/mL.)

Product Categories/Family for IFNL2 recombinant protein

AKT Signaling Pathway

NCBI and Uniprot Product Information

• NCBI GI #: 26024321
• NCBI GeneID: 282616
• NCBI Accession #: NP_742150.1
• NCBI GenBank Nucleotide #: NM_172138.1
• UniProt Accession #: Q8IZJ0; Q45KQ8; Q6VN55; Q8IWL7
• Molecular Weight: 22,288 Da
• NCBI Official Full Name: interferon lambda-2
• NCBI Official Synonym Full Names: interferon, lambda 2
• NCBI Official Symbol: IFNL2
• NCBI Official Synonym Symbols: IL28A; IL-28A
• NCBI Protein Information: interferon lambda-2; IFN-lambda-2; interleukin-28A; cytokine Zcyto20; interferon lambda 2; interferon-lambda 2; interleukin 28A (interferon, lambda 2)
• UniProt Protein Name: Interferon lambda-2
• Protein Family: Interferon
• UniProt Gene Name: IFNL2
• UniProt Synonym Gene Names: IL28A; ZCYTO20; IFN-lambda-2; IL-28A
• UniProt Entry Name: IFNL2_HUMAN

NCBI Description

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

Uniprot Description

IL28A: Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family.

Protein type: Secreted, signal peptide; Secreted; Cytokine

Chromosomal Location of Human Ortholog: 19q13.13

Cellular Component: extracellular space

Molecular Function: cytokine activity

Biological Process: positive regulation of immune response; mucosal immune response; JAK-STAT cascade; defense response to virus