IL29 Blocking Peptide | IFNL1 blocking peptide

IL29 Antibody (Center) Blocking Peptide

• Gene Names: IFNL1; IL29; IL-29
• Synonyms: IL29; IL29 Antibody (Center) Blocking Peptide; ZCYTO21; IFNL1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody MBS9212661 was selected from the Center region of human IL29. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 200

• Cellular Location: Secreted.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for IFNL1 blocking peptide

Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

NCBI and Uniprot Product Information

• NCBI GI #: 55976527
• NCBI GeneID: 282618
• UniProt Accession #: Q8IU54; Q17R34; A0AV25
• Molecular Weight: 21,898 Da
• NCBI Official Full Name: Interferon lambda-1
• NCBI Official Synonym Full Names: interferon lambda 1
• NCBI Official Symbol: IFNL1
• NCBI Official Synonym Symbols: IL29; IL-29
• NCBI Protein Information: interferon lambda-1
• UniProt Protein Name: Interferon lambda-1
• Protein Family: Interferon
• UniProt Gene Name: IFNL1
• UniProt Synonym Gene Names: IL29; ZCYTO21; IFN-lambda-1; IL-29
• UniProt Entry Name: IFNL1_HUMAN

NCBI Description

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

Uniprot Description

IL29: Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family.

Protein type: Secreted; Secreted, signal peptide; Cytokine; Cell cycle regulation

Chromosomal Location of Human Ortholog: 19q13.13

Cellular Component: extracellular region; extracellular space; interleukin-28 receptor complex

Molecular Function: interleukin-28 receptor binding; receptor binding

Biological Process: defense response to virus; innate immune response; negative regulation of cell proliferation; negative regulation of interleukin-13 production; negative regulation of interleukin-5 production; negative regulation of memory T cell differentiation; negative regulation of T cell differentiation; negative regulation of T-helper 2 type immune response; negative regulation of transcription, DNA-dependent; positive regulation of immune response; positive regulation of interferon-gamma production; positive regulation of JAK-STAT cascade; positive regulation of MHC class I biosynthetic process; positive regulation of transcription, DNA-dependent; positive regulation of tyrosine phosphorylation of STAT protein