Interferon gamma Receptor 1/IFN-gamma R1/CD119 Recombinant Protein | IFN-gamma R1/CD119 recombinant protein
Recombinant Mouse Interferon gamma Receptor 1/IFN-gamma R1/CD119 Protein (C-Fc)
Gene Names
Ifngr1; Ifgr; CD119; Ifngr; Nktar; IFN-gammaR
Purity
>95% as determined by reducing SDS-PAGE.
Synonyms
Interferon gamma Receptor 1/IFN-gamma R1/CD119; Recombinant Mouse Interferon gamma Receptor 1/IFN-gamma R1/CD119 Protein (C-Fc); CD119; Interferon gamma receptor 1; IFNGR1; IFN-gamma receptor 1; IFN-gamma-R1; CD119 antigen; IFN gamma receptor 1; IFNGR; immune interferon receptor 1; interferon gamma receptor 1; interferon-gamma receptor alpha chain; IFN-gamma R1/CD119 recombinant protein
Host
Human Cells
Purity/Purification
>95% as determined by reducing SDS-PAGE.
Form/Format
Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Sequence Positions
Ala26-Asp253
Sequence Length
477
Species
Mouse
Endotoxin
<1.0 EU per mug as determined by LAL test.
Fusion Tag
C-Fc
Preparation and Storage
Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
Related Product Information for IFN-gamma R1/CD119 recombinant protein
The tetrameric receptor complex for IFNgamma consists of two subunits, IFNGR1 (IFNgamma Ralpha) and IFNGR2 (IFNgamma Rbeta), through which the dimeric IFN-gamma exerts its biological functions, including antiviral, antiproliferation and immune-modulatory activity in mammals. Both IFNGR1 and IFNGR2 are single transmembrane proteins belonging to the class II cytokine family. FNGR1, widely expressed in most host cells, is essential for IFNgamma binding, receptor trafficking, and signal transduction. IFNGR1 possesses an intracellular Janus tyrosine kinase (JAK) 1 binding site, a signal transducer and activator of transcription 1 (STAT1) binding site. The resulting STAT1 homodimers translocate from the cytoplasm to the nucleus and bind to the interferon-gamma activated sequence (GAS) promoter to induce expression of downstream interferon stimulated genes (ISGs).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Molecular Mass: 53.0 kDa
Actual Protein Molecular Mass: 72-94 kDa
Actual Protein Molecular Mass: 72-94 kDa
NCBI Official Full Name
interferon gamma receptor 1
NCBI Official Synonym Full Names
interferon gamma receptor 1
NCBI Official Symbol
Ifngr1
NCBI Official Synonym Symbols
Ifgr; CD119; Ifngr; Nktar; IFN-gammaR
NCBI Protein Information
interferon gamma receptor 1
UniProt Protein Name
Interferon gamma receptor 1
UniProt Gene Name
Ifngr1
UniProt Synonym Gene Names
Ifngr; IFN-gamma receptor 1; IFN-gamma-R1; IFN-gamma-R-alphaBy similarityManual assertion inferred from sequence similarity toiUniProtKB:P15260Â (INGR1_HUMAN)
Uniprot Description
Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:2530582, PubMed:2532365, PubMed:2137461, PubMed:2531896, PubMed:2530216). Ligand binding stimulates activation of the JAK/STAT signaling pathway ().
Research Articles on IFN-gamma R1/CD119
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Product Notes
The IFN-gamma R1/CD119 ifngr1 (Catalog #AAA2553536) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is Ala26-Asp253. It is sometimes possible for the material contained within the vial of "Interferon gamma Receptor 1/IFN-gamma R1/CD119, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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