Interferon alpha/beta Receptor 2/IFNAR2 Recombinant Protein | IFNAR2 recombinant protein

Recombinant Human Interferon alpha/beta Receptor 2/IFNAR2 Protein (C-6His)

Cat. Num. AAA2552825

• Gene Names: IFNAR2; IFN-R; IMD45; IFNABR; IFNARB; IFN-alpha-REC
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Interferon alpha/beta Receptor 2/IFNAR2; Recombinant Human Interferon alpha/beta Receptor 2/IFNAR2 Protein (C-6His); Interferon Alpha/Beta Receptor 2; IFN-R-2; IFN-Alpha Binding Protein; IFN-Alpha/Beta Receptor 2; Interferon Alpha Binding Protein; Type I Interferon Receptor 2; IFNAR2; IFNABR; IFNARB; IFNAR2 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
• Sequence Positions: Ile27-Lys243
• Sequence Length: 331

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for IFNAR2 recombinant protein

Interferon alpha/beta Receptor 2 (IFN-alpha/beta R2) is a single-pass type I membrane protein which belongs to the type II cytokine receptor family. It complexes with IFN-alpha/beta R1 to form the signaling receptor complex for the family of alpha and beta IFN subtypes. By alternative splicing, IFN-alpha/beta R2 can exist as a secreted soluble protein or as a type I membrane protein. IFN-alpha/beta R2 is the principal ligand binding subunit of the receptor. Ligand binding is stabilized by the subsequent association with IFN-alpha/beta R1, resulting in the formation of a signaling ternary receptor complex. IFNAR2 was detected in most lymphocytes, monocytes, and granulocytes, although IFNAR2 expression was higher in the monocytes and granulocytes than in the lymphocytes. Among the lymphocyte subsets, IFNAR2 showed high expression in natural killer (NK) cells and low expression in T lymphocytes. Isoform 1 and isoform 3 of IFNAR2 are directly involved in signal transduction due to their interaction with the TYR kinase, JAK1. Isoform 1 also interacts with the transcriptional factors, STAT1 and STAT2. Both forms are potent inhibitors of type I IFN activity.

NCBI and Uniprot Product Information

• NCBI GI #: 19923129
• NCBI GeneID: 3455
• NCBI Accession #: NP_000865.2
• NCBI GenBank Nucleotide #: NM_000874.4
• UniProt Accession #: P48551; Q15467; Q6FHD7; A8KAJ4; D3DSE8; D3DSE9
• Molecular Weight: Molecular Mass: 25.8 kDa; Actual Protein Molecular Mass: 46 kDa
• NCBI Official Full Name: interferon alpha/beta receptor 2 isoform b
• NCBI Official Synonym Full Names: interferon alpha and beta receptor subunit 2
• NCBI Official Symbol: IFNAR2
• NCBI Official Synonym Symbols: IFN-R; IMD45; IFNABR; IFNARB; IFN-alpha-REC
• NCBI Protein Information: interferon alpha/beta receptor 2
• UniProt Protein Name: Interferon alpha/beta receptor 2
• Protein Family: Interferon alpha/beta receptor
• UniProt Gene Name: IFNAR2
• UniProt Synonym Gene Names: IFNABR; IFNARB; IFN-R-2; IFN-alpha binding protein; IFN-alpha/beta receptor 2

NCBI Description

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950).