IFNA7 recombinant protein

IFNA7 Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8118611

• Gene Names: IFNA7; IFNA-J; IFN-alphaJ
• Purity: >95 % as determined by SDS-PAGE.
• Synonyms: IFNA7; IFNA7 Protein; Human; Recombinant (His Tag); Human IFNA7 Protein (His Tag); interferon; alpha 7; IFN-alphaJ Protein; IFNA-J Protein; IFNA7 recombinant protein

• Host: Yeast
• Purity/Purification: >95 % as determined by SDS-PAGE.
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Sequence Positions: 176aa
• Sequence: Cys24-Asp189

• Species: Human
• Tag: C-His
• Predicted N Terminal: Cys24
• Protein Construction: |A DNA sequence encoding the human IFNA7 (NP_066401.2) (Cys24-Asp189) was expressed with a polyhistidine tag at the C-terminus
• Activity: Measured in antiviral assays using WISH cells infected with vesicular stomatitis virus. The ED50 for this effect is 3.0-15.0pg/mL.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; Shipping: They are shipped out with blue ice pack

Testing Data

Testing Data

(Measured in antiviral assays using WISH cells infected with vesicular stomatitis virus. The ED50 for this effect is 3.0-15.0pg/mL.)

Related Product Information for IFNA7 recombinant protein

Interferon alpha-7(IFNA7) is a member of the interferon family. Interferons belong to the group of the regulatory glycoproteins, of low molecular mass. They are the products of infected cell-genome, but not virus, as a consequence of the cause answer by different inductors. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. They allow communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors. IFNs have other functions: they activate immune cells, such as natural killer cells and macrophages; they increase recognition of infection or tumor cells by up-regulating antigen presentation to T lymphocytes, and they increase the ability of uninfected host cells to resist new infection by the virus. Certain host symptoms, such as aching muscles and fever, are related to the production of IFNs during infection. Human IFN is divided on the sequence of amino-acids into three groups: Alpha, Beta, and Gamma interferons.

References

De Veer MJ, et al. (2001) Functional classification of interferon-stimulated genes identified using microarrays. J Leukoc Biol. 69 (6): 912-20.Liu YJ. (2005) IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu Rev Immunol. 23: 275-306.Fensterl V, et al. (2009) Interferons and viral infections. Biofactors. 35 (1): 14-20.

NCBI and Uniprot Product Information

• NCBI GI #: 71143135
• NCBI GeneID: 3444
• NCBI Accession #: NP_066401.2
• NCBI GenBank Nucleotide #: NM_021057.2
• UniProt Accession #: P01567; Q14607; Q5VV14
• Molecular Weight: 22,107 Da
• NCBI Official Full Name: interferon alpha-7
• NCBI Official Synonym Full Names: interferon, alpha 7
• NCBI Official Symbol: IFNA7
• NCBI Official Synonym Symbols: IFNA-J; IFN-alphaJ
• NCBI Protein Information: interferon alpha-7; IFN-alpha 7; IFN-alpha-7; IFN-alpha-J1; interferon alpha-J; interferon alpha-J1; leIF J
• UniProt Protein Name: Interferon alpha-7
• Protein Family: Interferon
• UniProt Gene Name: IFNA7
• UniProt Synonym Gene Names: IFN-alpha-7; LeIF J; IFN-alpha-J1

Uniprot Description

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.