Interferon alpha 2/IFNA2 Recombinant Protein | IFNA2 recombinant protein

Interferon alpha 2/IFNA2 Protein, Human, Recombinant

Cat. Num. AAA8118686

• Gene Names: IFNA2; IFNA; INFA2; IFNA2B; IFN-alphaA
• Purity: >95 % as determined by SDS-PAGE.
• Synonyms: Interferon alpha 2/IFNA2; Interferon alpha 2/IFNA2 Protein; Human; Recombinant; Human Interferon alpha 2/IFNA2 Protein; interferon; alpha 2; IFN-alphaA Protein; IFNA Protein; IFNA2B Protein; IFNAB Protein; INFA2 Protein; Interferon alpha 2 Protein; IFNA2 recombinant protein

• Host: Yeast
• Purity/Purification: >95 % as determined by SDS-PAGE.
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Sequence Positions: 165aa
• Sequence: Cys24-Glu188

• Species: Human
• Predicted N Terminal: Cys24
• Protein Construction: |A DNA sequence encoding the human IFNA2A (P01563.1) (Cys24-Glu188) was expressed
• Activity: Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus(VSV). The EC50 for this effect is typically 0.6-4.2pg/mL.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; Shipping: They are shipped out with blue ice pack

Testing Data

Testing Data

(Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus(VSV). The EC50 for this effect is typically 0.6-4.2pg/mL.)

Related Product Information for IFNA2 recombinant protein

IFNA2 (Interferon Alpha 2) is a Protein Coding gene. This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Type I Interferons (IFNs) are well-known cytokines that exert antiviral activity, antitumor activity, and immunomodulatory effects. Interferon tau (IFNT), a type I IFN similar to alpha IFNs (IFNA), is the pregnancy recognition signal produced by the ruminant conceptus. Among the IFN-alpha genes, a total of 28 different sequence variants have been described. The three principal subtypes of IFNalpha-2 are designated alpha-2a, alpha-2b, and alpha-2c. IFNalpha-2b is being the predominant allele while IFNalpha-2a is less predominant and IFNalpha-2c only a minor allelic variant.

References

Wang, et al. (2004) Fever of recombinant human interferon-alpha is mediated by opioid domain interaction with opioid receptor inducing prostaglandin E2. J Neuroimmunol. 156(1-2): 107-12.Groopman JE, et al. (1984) Recombinant alpha-2 interferon therapy for Kaposi's sarcoma associated with the acquired immunodeficiency syndrome. Ann Intern Med. 100(5): 671-6.Krueger JM, et al. (1987) Interferon alpha-2 enhances slow-wave sleep in rabbits. Int J Immunopharmacol. 9(1): 23-30.

NCBI and Uniprot Product Information

• NCBI GI #: 11067751
• NCBI GeneID: 3440
• NCBI Accession #: NP_000596.2
• NCBI GenBank Nucleotide #: NM_000605.3
• UniProt Accession #: P01563; P01564; Q14606; Q6DJX8; Q96KI6; H2DF54; H2DF55
• Molecular Weight: 21,550 Da
• NCBI Official Full Name: interferon alpha-2
• NCBI Official Synonym Full Names: interferon, alpha 2
• NCBI Official Symbol: IFNA2
• NCBI Official Synonym Symbols: IFNA; INFA2; IFNA2B; IFN-alphaA
• NCBI Protein Information: interferon alpha-2; IFN-alpha-2; alpha-2a interferon; interferon alpha 2a; interferon alpha 2b; interferon alpha A; leIF A
• UniProt Protein Name: Interferon alpha-2
• UniProt Gene Name: IFNA2
• UniProt Synonym Gene Names: IFNA2A; IFNA2B; IFNA2C; IFN-alpha-2; LeIF A
• UniProt Entry Name: IFNA2_HUMAN

NCBI Description

This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Use of the recombinant form of this protein has been shown to be effective in reducing the symptoms and duration of the common cold. [provided by RefSeq, Jun 2011]