Guinea Pig Interleukin 1beta converting enzyme ELISA Kit | ICE elisa kit
Guinea Pig Interleukin 1beta converting enzyme ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
Function: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis
By similarity.
Catalytic activity: Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.
Subunit structure: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The p20 subunit can also form a heterodimer with the epsilon isoform which then has an inhibitory effect. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NALP2 and whose function would be the activation of proinflammatory caspases. Interacts with CARD17/INCA and CARD18
By similarity.
Subcellular location: Cytoplasm.
Post-translational modification: The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
Sequence similarities: Belongs to the peptidase C14A family.Contains 1 CARD domain.
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Product Notes
The Guinea Pig ICE casp1 (Catalog #AAA721463) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA721463 ELISA Kit recognizes Guinea Pig ICE. It is sometimes possible for the material contained within the vial of "Interleukin 1beta converting enzyme, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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