Cholecystokinin A Receptor (CCKAR) Small Molecule | CCKAR small molecule

OVA Conjugated Cholecystokinin A Receptor (CCKAR)

Cat. Num. AAA2097375

• Gene Names: CCKAR; CCK-A; CCK1R; CCKRA; CCK1-R
• Reactivity: Human
• Applications: SDS-Page, Western Blot
• Purity: > 90%
• Synonyms: Cholecystokinin A Receptor (CCKAR); OVA Conjugated Cholecystokinin A Receptor (CCKAR); CCK-A; CCK1; CCKRA; CCK1R; Cholecystokinin Type 1 Receptor; CCKAR small molecule

• Reactivity: Human
• Purity/Purification: > 90%
• Form/Format: Freeze-dried powder
• Sequence Length: 428

• Applicable Applications for CCKAR small molecule: Immunogen, SDS-PAGE, Western Blot (WB)
• Expression System: Protein conjugation
• Tag: N-terminal His Tag
• Buffer Formulation: PBS, pH7.4.
• Fragment: Gly398-Ser412

Sequence Information

SDS-Page

Product Categories/Family for CCKAR small molecule

Signal transduction; Endocrinology; Hepatology; Hormone metabolism

NCBI and Uniprot Product Information

• NCBI GI #: 4502607
• NCBI GeneID: 886
• NCBI Accession #: NP_000721.1
• NCBI GenBank Nucleotide #: NM_000730.2
• UniProt Accession #: P32238; B2R9Z5
• Molecular Weight: 47,841 Da
• NCBI Official Full Name: cholecystokinin receptor type A
• NCBI Official Synonym Full Names: cholecystokinin A receptor
• NCBI Official Symbol: CCKAR
• NCBI Official Synonym Symbols: CCK-A; CCK1R; CCKRA; CCK1-R
• NCBI Protein Information: cholecystokinin receptor type A
• UniProt Protein Name: Cholecystokinin receptor type A
• Protein Family: Cholecystokinin receptor
• UniProt Gene Name: CCKAR
• UniProt Synonym Gene Names: CCKRA; CCK-A receptor; CCK-AR; CCK1-R

NCBI Description

This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008]

Uniprot Description

CCKAR: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 4p15.2

Cellular Component: integral component of plasma membrane; plasma membrane

Molecular Function: cholecystokinin receptor activity; peptide binding

Biological Process: axonogenesis; cellular response to hormone stimulus; cholecystokinin signaling pathway; digestion; elevation of cytosolic calcium ion concentration; feeding behavior; forebrain development; G-protein coupled receptor signaling pathway; neuron migration; phospholipase C-activating G-protein coupled receptor signaling pathway; regulation of hormone secretion; response to nutrient; response to peptide