Thyroxine Binding Globulin Protein | SERPINA7 protein

Thyroxine Binding Globulin (TBG)

Cat. Num. AAA634564

• Gene Names: SERPINA7; TBG
• Applications: Gel Super Shift Assay
• Purity: Highly Purified; ~ 75%. SDS-PAGE Single band at ~55kD.
• Synonyms: Thyroxine Binding Globulin; Thyroxine Binding Globulin (TBG); SERPINA7 protein

• Host: Human serum
• Purity/Purification: Highly Purified; ~ 75%. SDS-PAGE Single band at ~55kD.
• Form/Format: Supplied as lyophillized powder from 0.02M ammonium bicarbonate. May contain traces of buffer salts. Reconstitute in sterile PBS, pH >7.0

• Applicable Applications for SERPINA7 protein: Gel Shift Assay (GS/EMSA)
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for SERPINA7 protein

Molecular Biology; MB-Serum Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 205277441
• NCBI GeneID: 6906
• NCBI Accession #: NP_000345.2
• NCBI GenBank Nucleotide #: NM_000354.5
• UniProt Accession #: P05543; D3DUX1
• Molecular Weight: 55kD
• NCBI Official Full Name: thyroxine-binding globulin
• NCBI Official Synonym Full Names: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
• NCBI Official Symbol: SERPINA7
• NCBI Official Synonym Symbols: TBG
• NCBI Protein Information: thyroxine-binding globulin; serpin A7; T4-binding globulin; thyroxin-binding globulin; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
• UniProt Protein Name: Thyroxine-binding globulin
• Protein Family: Thyroxine-binding globulin
• UniProt Gene Name: SERPINA7
• UniProt Synonym Gene Names: TBG
• UniProt Entry Name: THBG_HUMAN

NCBI Description

There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012]

Uniprot Description

SERPINA7: Major thyroid hormone transport protein in serum. Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency). Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein- bound iodine but are euthyroid. Belongs to the serpin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: Xq22.2

Cellular Component: extracellular space; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; hormone binding

Biological Process: response to drug; response to peptide hormone stimulus; aging; response to vitamin A; response to corticosterone stimulus; post-embryonic development