Human Macrophage Scavenger Receptor 1 (MSR1) RTU ELISA Kit | MSR1 rtu elisa kit

Human Macrophage Scavenger Receptor 1 (MSR1) ELISA Kit

Cat. Num. AAA4501164

• Gene Names: MSR1; SRA; SR-A; CD204; SR-AI; phSR1; phSR2; SCARA1; SR-AII; SR-AIII
• Reactivity: Human
• Synonyms: Macrophage Scavenger Receptor 1 (MSR1); Human Macrophage Scavenger Receptor 1 (MSR1) ELISA Kit; CD204; MSR1; SCARA1; SR-A; PhSR1; PhSR2; Macrophage acetylated LDL receptor I and II; Scavenger receptor class A member 1; MSR1 rtu elisa kit

• Reactivity: Human
• Sequence Length: 358

• Assay Type: Sandwich
• Samples: Tissue Homogenates, Cell Lysates or Other Biological Fluids.
• Detection Range: 0.312-20ng/mL
• Sensitivity: 0.133ng/mL
• RTU ELISA Kit's Advantage: The Ready-To-Use (RTU) Kits require fewer steps in setup and take less time to run. Detection Solutions are pre-diluted and total incubation time is shorter than many other ELISA Kits.
• Preparation and Storage: For unopened kits: All the reagents should be kept at 4 degree C upon receipt.; For opened kits: Once the kit is opened, the remaining reagents still need to be stored according to the above storage conditions. In addition, return the unused wells to the foil pouch containing the desiccant pack and reseal along entire edge of zip-seal.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for MSR1 rtu elisa kit

Test Principle: The microtiter plate provided in this kit has been pre-coated with an antibody specific to MSR1. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific to MSR1. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain MSR1, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of MSR1 in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 4505259
• NCBI GeneID: 4481
• NCBI Accession #: NP_002436.1
• NCBI GenBank Nucleotide #: NM_002445.3
• UniProt Accession #: P21757; O60505; P21759; Q45F10; D3DSP3
• Molecular Weight: 42,942 Da
• NCBI Official Full Name: macrophage scavenger receptor types I and II isoform type 2
• NCBI Official Synonym Full Names: macrophage scavenger receptor 1
• NCBI Official Symbol: MSR1
• NCBI Official Synonym Symbols: SRA; SR-A; CD204; SR-AI; phSR1; phSR2; SCARA1; SR-AII; SR-AIII
• NCBI Protein Information: macrophage scavenger receptor types I and II
• UniProt Protein Name: Macrophage scavenger receptor types I and II
• Protein Family: Macrophage scavenger receptor
• UniProt Gene Name: MSR1
• UniProt Synonym Gene Names: SCARA1

NCBI Description

This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]

Uniprot Description

Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL) (PubMed:2251254). Isoform III does not internalize acetylated LDL (PubMed:9548586).