Human Killer Cell Immunoglobulin Like Receptor 3DL1 (KIR3DL1) RTU ELISA Kit | KIR3DL1 rtu elisa kit

Human Killer Cell Immunoglobulin Like Receptor 3DL1 (KIR3DL1) ELISA Kit

Cat. Num. AAA4500587

• Gene Names: KIR3DL1; KIR; NKB1; NKAT3; NKB1B; NKAT-3; CD158E1; KIR3DL1/S1
• Reactivity: Human
• Synonyms: Killer Cell Immunoglobulin Like Receptor 3DL1 (KIR3DL1); Human Killer Cell Immunoglobulin Like Receptor 3DL1 (KIR3DL1) ELISA Kit; CD158E; HLA-BW4-specific inhibitory NK cell receptor; CD158 antigen-like family member E; Natural killer-associated transcript 3; p70 NK receptor CL-2/CL-11; KIR3DL1 rtu elisa kit

• Reactivity: Human
• Sequence Length: 444

• Assay Type: Sandwich
• Samples: Tissue Homogenates, Cell Lysates or Other Biological Fluids.
• Detection Range: 0.156-10ng/mL
• Sensitivity: 0.051ng/mL
• RTU ELISA Kit's Advantage: The Ready-To-Use (RTU) Kits require fewer steps in setup and take less time to run. Detection Solutions are pre-diluted and total incubation time is shorter than many other ELISA Kits.
• Preparation and Storage: For unopened kits: All the reagents should be kept at 4 degree C upon receipt.; For opened kits: Once the kit is opened, the remaining reagents still need to be stored according to the above storage conditions. In addition, return the unused wells to the foil pouch containing the desiccant pack and reseal along entire edge of zip-seal.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for KIR3DL1 rtu elisa kit

Test Principle: The microtiter plate provided in this kit has been pre-coated with an antibody specific to KIR3DL1. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific to KIR3DL1. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain KIR3DL1, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of KIR3DL1 in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 1016080639
• NCBI GeneID: 3811
• NCBI Accession #: NP_001309097.1
• NCBI GenBank Nucleotide #: NM_001322168.1
• UniProt Accession #: P43629; O43473; Q14946; Q16541
• Molecular Weight: 38,403 Da
• NCBI Official Full Name: killer cell immunoglobulin-like receptor 3DL1
• NCBI Official Synonym Full Names: killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1
• NCBI Official Symbol: KIR3DL1
• NCBI Official Synonym Symbols: KIR; NKB1; NKAT3; NKB1B; NKAT-3; CD158E1; KIR3DL1/S1
• NCBI Protein Information: killer cell immunoglobulin-like receptor 3DL1
• UniProt Protein Name: Killer cell immunoglobulin-like receptor 3DL1
• Protein Family: Killer cell immunoglobulin-like receptor
• UniProt Gene Name: KIR3DL1
• UniProt Synonym Gene Names: CD158E; NKAT3; NKB1; NKAT-3; p70 NK receptor CL-2/CL-11

NCBI Description

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

Uniprot Description

Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis.