C-Reactive Protein Cardiac Marker
C-Reactive Protein, Human (CRP, MGC88244, PTX 1, PTX1)
Purity
98% Purified by SDS-PAGE at 26kD.
Synonyms
C-Reactive Protein; Human (CRP; MGC88244; PTX 1; PTX1); C-Reactive Protein cardiac marker
Host
Human pleural fluid
Purity/Purification
98% Purified by SDS-PAGE at 26kD.
Form/Format
Supplied as a liquid in 10mM Tris, 100mM sodium chloride, 0.09% sodium azide, 2mM CA2+
Concentration
3.1mg/ml (varies by lot)
Preparation and Storage
May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for C-Reactive Protein cardiac marker
C-reactive protein (CRP) is an acute phase reactant. CRP is released by the body in response to acute injury, infection, or other inflammatory stimuli. Recent development of a high sensitivity assay for CRP (hs-CRP) has enabled investigation of this marker of systemic inflammation.
CRP and Atherosclerosis
Atheromatous plaques in diseased arteries typically contain inflammatory cells. Rupture of atheromatous plaque is thought to be the mechanism for acute myocardial infarction and acute coronary syndrome. The most common site of plaque rupture appears to be the shoulder region where inflammatory cells are most prominent. Thus the release of acute phase reactants as a response to inflammation have been proposed as a potential marker of an "unstable" atheromatous plaque and underlying atherosclerosis.
Studies have shown a positive association between CRP and coronary artery disease. In a survey of 388 British men aged 50-69, the prevalence of coronary artery disease increased 1.5 fold for each doubling of CRP level (Mendall MA, Patel P, Ballam L, et al. C-reactive protein and its relation to cardiovascular risk factor: A population based cross sectional study. BMJ. 1996;312:1061-1065.)
Multiple prospective studies have also demonstrated that baseline CRP is a good marker of future cardiovascular events (Riker P, Haughie P. Prospective studies of C-reactive protein as a risk factor for cardiovascular disease. J Investig Med. 1998;46:391-395.)
It has been suggested that CRP may be a good marker of cardiovascular risk in addition to lipid level.
CRP and Atherosclerosis
Atheromatous plaques in diseased arteries typically contain inflammatory cells. Rupture of atheromatous plaque is thought to be the mechanism for acute myocardial infarction and acute coronary syndrome. The most common site of plaque rupture appears to be the shoulder region where inflammatory cells are most prominent. Thus the release of acute phase reactants as a response to inflammation have been proposed as a potential marker of an "unstable" atheromatous plaque and underlying atherosclerosis.
Studies have shown a positive association between CRP and coronary artery disease. In a survey of 388 British men aged 50-69, the prevalence of coronary artery disease increased 1.5 fold for each doubling of CRP level (Mendall MA, Patel P, Ballam L, et al. C-reactive protein and its relation to cardiovascular risk factor: A population based cross sectional study. BMJ. 1996;312:1061-1065.)
Multiple prospective studies have also demonstrated that baseline CRP is a good marker of future cardiovascular events (Riker P, Haughie P. Prospective studies of C-reactive protein as a risk factor for cardiovascular disease. J Investig Med. 1998;46:391-395.)
It has been suggested that CRP may be a good marker of cardiovascular risk in addition to lipid level.
Product Categories/Family for C-Reactive Protein cardiac marker
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Product Notes
The C-Reactive Protein (Catalog #AAA651847) is a Cardiac Marker produced from Human pleural fluid and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "C-Reactive Protein, Cardiac Marker" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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