Alpha 2 Macroglobulin Native Protein | A2M native protein

Human Alpha 2 Macroglobulin

Cat. Num. AAA318176

• Gene Names: A2M; A2MD; CPAMD5; FWP007; S863-7; DKFZp779B086
• Purity: >95% pure (SDS-PAGE)
• Synonyms: Alpha 2 Macroglobulin; Human Alpha 2 Macroglobulin; Human Plasma Alpha-2 Macroglobulin; A2M native protein

• Host: Human Plasma
• Specificity: Alpha 2 Macroglobulin
• Purity/Purification: >95% pure (SDS-PAGE)
• Form/Format: Purified; Reconstitute with distilled water.; Lyophilized from 30mM Sodium phosphate, pH 7.0 containing 1mg glycine
• Concentration: 3.37 mg/mL (prior to lyophilization) (varies by lot)
• Sequence Length: 1474

• Application Notes: Specific methodologies have not been tested using this product.
• Preservative: No
• Lyophilized: Yes
• Warnings: All human source materials have tested negative for HIV 1, HIV 2 and tested non-reactive for anti-HCV, anti-HBc antibodies and HBsAg by FDA required tests. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious.
• Important Note: Centrifuge before opening to ensure complete recovery of vial contents.
• Preparation and Storage: Store at -20 degree C. Avoid multiple freeze/thaw cycles.

Related Product Information for A2M native protein

Human Alpha 2 Macroglobulin
Human Plasma Alpha-2 Macroglobulin

Product Categories/Family for A2M native protein

Purified Proteins and Bioactive Peptides

NCBI and Uniprot Product Information

• NCBI GI #: 112911
• NCBI GeneID: 2
• UniProt Accession #: P01023; Q13677; Q59F47; Q5QTS0; Q68DN2; Q6PIY3; Q6PN97; Q9BQ22
• NCBI Official Full Name: Alpha-2-macroglobulin
• NCBI Official Synonym Full Names: alpha-2-macroglobulin
• NCBI Official Symbol: A2M
• NCBI Official Synonym Symbols: A2MD; CPAMD5; FWP007; S863-7; DKFZp779B086
• NCBI Protein Information: alpha-2-macroglobulin; alpha-2-M; OTTHUMP00000196829; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
• UniProt Protein Name: Alpha-2-macroglobulin
• Protein Family: Alpha-2-macroglobulin
• UniProt Gene Name: A2M
• UniProt Synonym Gene Names: CPAMD5
• UniProt Entry Name: A2MG_HUMAN

NCBI Description

Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq]

Uniprot Description

Function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Subunit structure: Homotetramer; disulfide-linked. Ref.8 Ref.10

Subcellular location: Secreted Ref.8.

Tissue specificity: Secreted in plasma. Ref.8

Developmental stage: Contrary to the rat protein, which is an acute phase protein, this protein is always present at high levels in circulation.

Sequence similarities: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. [View classification]

Sequence caution: The sequence AAT02228.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence BAD92851.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.