Complement C1s Enzyme | C1S enzyme

Human Complement C1s

Cat. Num. AAA147347

• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Synonyms: Complement C1s; Human Complement C1s; Complement C1s Human; Complement C1s subcomponent; C1 esterase; Complement component 1 subcomponent s; C1S; C1S Human; C1S enzyme

• Host: Human Plasma
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE.
• Form/Format: 10mM sodium phosphate and 145mM NaCl, pH7.2.; Sterile Filtered solution.

• Human Virus Test: Plasma from each donor has been tested and found negative for antibody to HIV-1, HIV-2, HCV, HTLV-I &II, STS and HBSAG.
• Preparation and Storage: Human C1s is stable at 4 degree C if entire vial will be used within 2-4 weeks.; Store, frozen below -20 degree C for longer periods of time.; For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).; Avoid multiple freeze-thaw cycles.

Related Product Information for C1S enzyme

Introduction: C1s enzyme (a subunit of the C1 complex) is the activated form of C1s proenzyme which is the first complement component in the classical pathway of complement. C1s proenzyme is an inactive zymogen until C1 is activated. C1 is a non-covalent calcium-dependent complex containing1 C1q, 2 C1r and 2 C1s molecules.The binding of multiple arms to immune complexes causesthe production of 2 proteases that cleave and activate the 2 C1s protease zymogens in the complex by the C1r proteins. This activation of C1s proenzyme results in its cleavage into 2 C1s chains of 58,000 and 28,000 Dalton.
Description: Human Complement C1s produced in Human plasma having a molecular mass of 86kDa.

Product Categories/Family for C1S enzyme

ENZYMES

NCBI and Uniprot Product Information

• NCBI GI #: 4502495
• NCBI GeneID: 716
• NCBI Accession #: NP_001725.1
• NCBI GenBank Nucleotide #: NM_001734.3
• UniProt Accession #: P09871; Q9UCU7; Q9UCU8; Q9UCU9; Q9UCV0; Q9UCV1; Q9UCV2; Q9UCV3; Q9UCV4; Q9UCV5; Q9UM14; D3DUT4
• Molecular Weight: 76,684 Da
• NCBI Official Full Name: complement C1s subcomponent
• NCBI Official Synonym Full Names: complement component 1, s subcomponent
• NCBI Official Symbol: C1S
• NCBI Protein Information: complement C1s subcomponent; C1 esterase; basic proline-rich peptide IB-1; complement component 1 subcomponent s
• UniProt Protein Name: Complement C1s subcomponent
• Protein Family: Complement C1s subcomponent
• UniProt Gene Name: C1S
• UniProt Entry Name: C1S_HUMAN

NCBI Description

This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. [provided by RefSeq, Mar 2009]

Uniprot Description

C1S: C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. Defects in C1S are the cause of complement component C1s deficiency (C1SD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. Belongs to the peptidase S1 family.

Protein type: Protease; EC 3.4.21.42

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: extracellular region

Molecular Function: identical protein binding; protein binding; serine-type endopeptidase activity; calcium ion binding

Biological Process: innate immune response; proteolysis; complement activation, classical pathway; complement activation

Disease: Complement Component C1s Deficiency