Troponin T Native Protein | Tnnt2 native protein

Troponin T protein

Cat. Num. AAA537236

• Gene Names: Tnnt2; Ctt; CTTG; Tnnt3; RATCTTG
• Purity: > 95% pure
• Synonyms: Troponin T; Troponin T protein; Cardiac Troponin T protein; Tnnt2 native protein

• Host: Human
• Purity/Purification: > 95% pure
• Form/Format: 6M Urea, 250mM NaCl, 50mM Tris.HCl, 15mM B-mercaptoethanol, 1 mM EDTA, pH 7.2.
• Sequence Length: 289

• Source Note: Human cardiac tissue
• Protein Type: Native
• Biological Significance: Troponin is a complex of three regulatory proteins that is integral to muscle contraction in skeletal and cardiac muscle, but not smooth muscle. Discussions of troponin often pertain to its functional characteristics and/or to its usefulness as a marker for various heart disorders. Troponin T is a part of the troponin complex. It binds to tropomyosin, interlocking them to form a troponin-tropomyosin complex.
• Biohazard Information: Donors tested negative for HBsAg, and for HIV-1, HIV-2, and HCV antibodies by an FDA approved tests. This material contains sodium azide as a preservative, take appropriate precautions.
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
• Preparation and Storage: Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles.

Related Product Information for Tnnt2 native protein

Purified native Human Troponin T protein

Product Categories/Family for Tnnt2 native protein

Cardiac Markers; Native Protein

NCBI and Uniprot Product Information

• NCBI GI #: 207522
• NCBI GeneID: 24837
• UniProt Accession #: P50753
• Molecular Weight: 34,452 Da
• NCBI Official Full Name: troponin T
• NCBI Official Synonym Full Names: troponin T type 2 (cardiac)
• NCBI Official Symbol: Tnnt2
• NCBI Official Synonym Symbols: Ctt; CTTG; Tnnt3; RATCTTG
• NCBI Protein Information: troponin T, cardiac muscle
• UniProt Protein Name: Troponin T, cardiac muscle
• Protein Family: Troponin
• UniProt Gene Name: Tnnt2
• UniProt Synonym Gene Names: TnTc; cTnT
• UniProt Entry Name: TNNT2_RAT

NCBI Description

tropomyosin-binding subunit of troponin; confers calcium-sensitivy to actinomysin ATPase activity in striated muscle [RGD, Feb 2006]

Uniprot Description

TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing.

Protein type: Motor; Motility/polarity/chemotaxis

Cellular Component: sarcomere; troponin complex; myofibril; cytoplasm; striated muscle thin filament

Molecular Function: protein binding, bridging; troponin C binding; structural constituent of cytoskeleton; troponin I binding; ATPase activity; tropomyosin binding; actin binding

Biological Process: actin crosslink formation; protein heterooligomerization; metabolic process; atrial cardiac muscle morphogenesis; regulation of muscle contraction; heart development; regulation of muscle filament sliding speed; sarcomere organization; regulation of heart contraction; muscle filament sliding; muscle contraction; positive regulation of ATPase activity; ventricular cardiac muscle morphogenesis; response to calcium ion; negative regulation of ATPase activity; cardiac muscle contraction