PAP native protein

PAP protein (> 40% pure)

Cat. Num. AAA537789

• Gene Names: ACPP; ACP3; 5'-NT; ACP-3
• Applications: User optimized
• Purity: > 40% pure
• Synonyms: PAP; PAP protein (> 40% pure); PAP protein; PAP antigen; Prostatic Acid Phosphatase protein; PAP native protein

• Host: Human
• Purity/Purification: > 40% pure
• Form/Format: Supplied 0.2 micron filtered in 150mM NaCl, 9.5mM Sodium Phosphate Monobasic, 40.5mM Sodium Phosphate Dibasic, pH 7.6 with 0.05% NaN3
• Sequence Length: 386

• Applicable Applications for PAP native protein: User optimized
• Source Note: Human seminal fluid
• Protein Type: Native
• Biological Significance: Prostatic acid phosphatase (PAP), also prostatic specific acid phosphatase (PSAP), is an enzyme produced by the prostate. It may be found in increased amounts in men who have prostate cancer or other diseases. The highest levels of acid phosphatase are found in metastasized prostate cancer.
• Biohazard Information: Donor samples were tested and found to be negative for HIV I/II, and HCV antibodies, and Hepatitis B surface antigen. Nonetheless caution should be used when handling this material as there is a margin of error in all tests. This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
• Preparation and Storage: Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles.

Related Product Information for PAP native protein

Purified native Human PAP protein (> 40% pure)

Product Categories/Family for PAP native protein

Cancer; Native Protein

NCBI and Uniprot Product Information

• NCBI GI #: 6382064
• NCBI GeneID: 55
• NCBI Accession #: NP_001090.2
• NCBI GenBank Nucleotide #: NM_001099.4
• UniProt Accession #: P15309; Q5FBY0; Q96KY0; Q96QK9; Q96QM0; D3DNC6
• Molecular Weight: 51 kDa
• NCBI Official Full Name: prostatic acid phosphatase isoform PAP
• NCBI Official Synonym Full Names: acid phosphatase, prostate
• NCBI Official Symbol: ACPP
• NCBI Official Synonym Symbols: ACP3; 5'-NT; ACP-3
• NCBI Protein Information: prostatic acid phosphatase
• UniProt Protein Name: Prostatic acid phosphatase
• Protein Family: Papain
• UniProt Gene Name: ACPP
• UniProt Synonym Gene Names: PAP; 5'-NT; TMPase
• UniProt Entry Name: PPAP_HUMAN

NCBI Description

This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]

Uniprot Description

ACPP: A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma. Belongs to the histidine acid phosphatase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.2; Phosphatase; Cofactor and Vitamin Metabolism - riboflavin; EC 3.1.3.5; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3q22.1

Cellular Component: multivesicular body; extracellular space; Golgi cisterna; apical part of cell; lysosomal membrane; integral to membrane; plasma membrane; intracellular; vesicle membrane; nucleus; secretory granule; filopodium

Molecular Function: 5'-nucleotidase activity; choline binding; identical protein binding; acid phosphatase activity; protein homodimerization activity; phosphoric monoester hydrolase activity; thiamin phosphate phosphatase activity

Biological Process: thiamin metabolic process; dephosphorylation; positive regulation of adenosine receptor signaling pathway; nucleotide metabolic process; regulation of sensory perception of pain; adenosine metabolic process; purine base metabolic process