Factor VII Native Protein | F7 native protein

Factor VII protein

Cat. Num. AAA537550

• Gene Names: F7; SPCA
• Applications: User optimized
• Purity: > 95% pure
• Synonyms: Factor VII; Factor VII protein; Complement Factor VII; F7 native protein

• Host: Human
• Purity/Purification: > 95% pure
• Form/Format: 20mM Tris-HCL, 0.1M NaCl, 1mM Benzamidine pH 7.4.
• Sequence Length: 466

• Applicable Applications for F7 native protein: User optimized
• Source Note: Human plasma
• Protein Type: Native
• Biological Significance: Factor VII is one of the central proteins in the coagulation cascade. It is an enzyme of the serine protease class. The main role of factor VII is to initiate the process of coagulation in conjunction with tissue factor (TF/factor III).
• Biohazard Information: Donor samples were tested and found to be negative for Anti-HIV1/2, Anti-HTLV I & II, HBsAg, Anti-HCV, Syphilis, HBC Ab, HIV-1 p24 Ag or HIV-1 RNA, HCV RNA and HBV RNA. Nonetheless caution should be used when handling this material as there is a margin of error in all tests. Donors were also screened for CJD (Creutzfeldt-Jakob Disease).
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
• Preparation and Storage: Aliquot and store at -70 degree C or lower. Avoid repeated freeze/thaw cycles

Related Product Information for F7 native protein

Purified native Human Factor VII protein

Product Categories/Family for F7 native protein

Proteases; Inhibitors; & Enzymes; Native Protein

NCBI and Uniprot Product Information

• NCBI GI #: 180334
• NCBI GeneID: 2155
• UniProt Accession #: P08709; Q14339; Q5JVF1; Q5JVF2; Q9UD52; Q9UD53; Q9UD54; B0YJC8
• Molecular Weight: 50 kDa
• NCBI Official Full Name: factor VII
• NCBI Official Synonym Full Names: coagulation factor VII (serum prothrombin conversion accelerator)
• NCBI Official Symbol: F7
• NCBI Official Synonym Symbols: SPCA
• NCBI Protein Information: coagulation factor VII
• UniProt Protein Name: Coagulation factor VII
• Protein Family: Factor VIII intron 22 protein
• UniProt Gene Name: F7
• UniProt Synonym Gene Names: SPCA
• UniProt Entry Name: FA7_HUMAN

NCBI Description

This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Uniprot Description

F7: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium. Defects in F7 are the cause of factor VII deficiency (FA7D). A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.21.21; Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted; Protease; Apoptosis

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: extracellular space; endoplasmic reticulum lumen; Golgi lumen; plasma membrane; extracellular region; vesicle

Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity; calcium ion binding; glycoprotein binding; receptor binding

Biological Process: circadian rhythm; organ regeneration; positive regulation of positive chemotaxis; positive regulation of blood coagulation; positive regulation of leukocyte chemotaxis; proteolysis; post-translational protein modification; peptidyl-glutamic acid carboxylation; positive regulation of protein kinase B signaling cascade; blood coagulation, extrinsic pathway; cellular protein metabolic process; response to vitamin K; response to estrogen stimulus; blood coagulation; positive regulation of cell migration

Disease: Myocardial Infarction, Susceptibility To; Factor Vii Deficiency