Beta 2 Microglobulin Native Protein | B2M native protein

Beta 2 Microglobulin >98% Pure

Cat. Num. AAA319753

• Applications: Western Blot
• Purity: >= 98% Beta 2 Microglobulin (Beta 2 Microglobutlin Content/Total Protein OD280 E0.1% = 1.65); (SDS-PAGE single band at ~ 12 kD).; Purified
• Synonyms: Beta 2 Microglobulin; Beta 2 Microglobulin >98% Pure; Beta 2 Microglobulin >= 98% Pure; B2M native protein

• Host: Human
• Purity/Purification: >= 98% Beta 2 Microglobulin (Beta 2 Microglobutlin Content/Total Protein OD280 E0.1% = 1.65); (SDS-PAGE single band at ~ 12 kD).; Purified
• Form/Format: Liquid
• Concentration: 1.97 mg/mL (Turbilatex {Spinreact}) (varies by lot)
• Sequence Length: 119

• Applicable Applications for B2M native protein: TIA, Western Blot (WB)
• Application Notes: Suitable for use in ELISA.
• Source: Human Urine
• Perservative: 0.05% Sodium Azide
• Buffer: 40 mM Phosphate, 150 mM Sodium Chloride, 1 mM EDTA Sodium Salt, pH 7.2 + 0.2.
• Warning: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.; Human Fluids tested negative for HBsAg, HCV Antibody and HIV 1 and 2 Antibodies. Also tested negative by PCR for HBV, HIV 1 and HCV. No test guarantees a product to be non-infectious. All materials should be handled as if potentially infectious. Generally accepted laboratory practices appropriate for infectious materials should be employed when handling this product.
• Preparation and Storage: Store 2-8 degree C.

Product Categories/Family for B2M native protein

Purified Proteins and Bioactive Peptides

NCBI and Uniprot Product Information

• NCBI GI #: 4757826
• NCBI GeneID: 567
• NCBI Accession #: NP_004039.1
• NCBI GenBank Nucleotide #: NM_004048.2
• Molecular Weight: 13,715 Da
• NCBI Official Full Name: beta-2-microglobulin
• NCBI Official Synonym Full Names: beta-2-microglobulin
• NCBI Official Symbol: B2M
• NCBI Protein Information: beta-2-microglobulin; beta-2-microglobin; beta chain of MHC class I molecules
• UniProt Protein Name: Beta-2-microglobulin
• Protein Family: Beta-2-microglobulin
• UniProt Gene Name: B2M
• UniProt Entry Name: B2MG_HUMAN

NCBI Description

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]

Uniprot Description

B2M: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Heterodimer of an alpha chain and a beta chain. Beta-2- microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Belongs to the beta-2-microglobulin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 15q21.1

Cellular Component: Golgi membrane; Golgi apparatus; extracellular space; phagocytic vesicle membrane; focal adhesion; membrane; early endosome membrane; endoplasmic reticulum lumen; cytoplasm; extracellular region; plasma membrane; MHC class I protein complex; external side of plasma membrane

Molecular Function: identical protein binding; protein binding

Biological Process: response to drug; regulation of immune response; viral reproduction; positive regulation of T cell mediated cytotoxicity; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; cytokine and chemokine mediated signaling pathway; T cell differentiation in the thymus; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of defense response to virus by virus; retinal homeostasis; antigen processing and presentation of peptide antigen via MHC class I; iron ion homeostasis; response to cadmium ion; response to molecule of bacterial origin; antigen processing and presentation of exogenous peptide antigen via MHC class I; innate immune response; protein refolding; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent

Disease: Hypoproteinemia, Hypercatabolic