alpha 2 Macroglobulin Native Protein | Pzp native protein

alpha 2 Macroglobulin protein

Cat. Num. AAA537019

• Gene Names: Pzp; A1m; A2m; MAM; AI893533
• Applications: User optimized
• Purity: > 95% pure
• Synonyms: alpha 2 Macroglobulin; alpha 2 Macroglobulin protein; A2M protein; alpha Macroglobulin 2; S863 7 protein; alpha Macroglobulin-2 protein; alpha 2 M protein; alpha Macroglobulin-2; DKFZp779B086 protein; alpha 2M protein; alpha Macroglobulin 2 protein; CPAMD5 protein; FWP007 protein; Pzp native protein

• Host: Human
• Purity/Purification: > 95% pure
• Form/Format: Lyophilized from 30mM Na3PO4, pH 7.0, with glycine as a stabilizer.
• Sequence Length: 1495

• Applicable Applications for Pzp native protein: User optimized
• Source Note: Human plasma
• Protein Type: Native
• Biological Significance: A major serum protein found at concentrations of 240 mg per 100 ml in men and 290 mg per 100 ml in women. Multifunctional, it promotes growth of mammalian cells in culture, stimulates the regeneration of lymphocytes in irradiated mice, possesses a transport function for zinc and is a proteinase inhibitor that controls the clotting and fibrinolytic system. Clinically levels are increased in liver cirrhosis, nephrotic syndrome, diabetes, and severe burn cases.
• Biohazard Information: Donor samples were tested and found to be negative for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.
• Preparation and Storage: Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles.

Related Product Information for Pzp native protein

Purified native Human alpha 2 Macroglobulin protein

Product Categories/Family for Pzp native protein

Proteases; Inhibitors; & Enzymes; Native Protein

NCBI and Uniprot Product Information

• NCBI GI #: 110347469
• NCBI GeneID: 11287
• NCBI Accession #: NP_031402.3
• NCBI GenBank Nucleotide #: NM_007376.4
• UniProt Accession #: Q61838; Q60628; Q6PEM2; E9QPW0
• Molecular Weight: 725 kDa
• NCBI Official Full Name: alpha-2-macroglobulin
• NCBI Official Synonym Full Names: pregnancy zone protein
• NCBI Official Symbol: Pzp
• NCBI Official Synonym Symbols: A1m; A2m; MAM; AI893533
• NCBI Protein Information: alpha-2-macroglobulin
• UniProt Protein Name: Alpha-2-macroglobulin
• Protein Family: Pregnancy zone protein
• UniProt Gene Name: A2m
• UniProt Synonym Gene Names: Pzp; Alpha-2-M
• UniProt Entry Name: A2M_MOUSE

Uniprot Description

PZP: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; protease inhibitor activity; endopeptidase inhibitor activity; protein complex binding

Biological Process: negative regulation of peptidase activity; embryo implantation