WAVE1 elisa kit
Phospho-WAVE1 (Tyr125) Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
WAVE1: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Belongs to the SCAR/WAVE family.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: actin cytoskeleton; cytoskeleton; focal adhesion; lamellipodium; mitochondrial outer membrane; protein complex; synapse
Molecular Function: actin binding; protein binding; protein complex binding; protein kinase A binding; Rac GTPase binding
Biological Process: actin filament polymerization; cell motility; cellular response to brain-derived neurotrophic factor stimulus; lamellipodium morphogenesis; positive regulation of Arp2/3 complex-mediated actin nucleation; positive regulation of nerve growth factor receptor signaling pathway; protein complex assembly; Rac protein signal transduction; receptor-mediated endocytosis
Research Articles on WAVE1
Similar Products
Product Notes
The Human, Mouse, Rat WAVE1 wasf1 (Catalog #AAA9501173) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501173 ELISA Kit recognizes Human, Mouse, Rat WAVE1. It is sometimes possible for the material contained within the vial of "WAVE1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
