Trk A elisa kit
Phospho-Trk A (Tyr680+Tyr681) Fluorometric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]
Uniprot Description
TrkA: a receptor tyrosine kinase of the Trk family. High affinity receptor for nerve growth factor, neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor. Known substrates include Shc, PI-3K, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system. Two splice variant isoforms have been described.
Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Trk family
Chromosomal Location of Human Ortholog: 1q23.1
Cellular Component: axon; cell soma; cell surface; dendrite; early endosome; early endosome membrane; endosome; integral component of plasma membrane; late endosome; late endosome membrane; plasma membrane; protein complex; receptor complex
Molecular Function: ATP binding; GPI-linked ephrin receptor activity; kinase binding; nerve growth factor binding; nerve growth factor receptor activity; neurotrophin binding; neurotrophin p75 receptor binding; protein binding; protein homodimerization activity; protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity
Biological Process: activation of MAPKK activity; aging; axon guidance; B cell differentiation; cellular response to amyloid-beta; cellular response to nicotine; circadian rhythm; detection of mechanical stimulus involved in sensory perception of pain; detection of temperature stimulus involved in sensory perception of pain; ephrin receptor signaling pathway; learning and/or memory; mechanoreceptor differentiation; microtubule-based movement; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of neuron apoptosis; nerve growth factor receptor signaling pathway; nerve growth factor signaling pathway; olfactory nerve development; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphoinositide-mediated signaling; positive regulation of ERK1 and ERK2 cascade; positive regulation of GTPase activity; positive regulation of neuron projection development; positive regulation of NF-kappaB transcription factor activity; positive regulation of programmed cell death; positive regulation of protein phosphorylation; positive regulation of Ras protein signal transduction; positive regulation of synaptic transmission, glutamatergic; positive regulation of synaptogenesis; programmed cell death involved in cell development; protein amino acid phosphorylation; protein autophosphorylation; response to activity; response to axon injury; response to drug; response to electrical stimulus; response to ethanol; response to hydrostatic pressure; response to nutrient levels; response to radiation; Sertoli cell development; sympathetic nervous system development
Disease: Insensitivity To Pain, Congenital, With Anhidrosis; Thyroid Carcinoma, Familial Medullary
Research Articles on Trk A
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Product Notes
The Human, Mouse, Rat Trk A ntrk1 (Catalog #AAA9501812) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501812 ELISA Kit recognizes Human, Mouse, Rat Trk A. It is sometimes possible for the material contained within the vial of "Trk A, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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