PLCG1 elisa kit
Phospho-PLCG1 (Tyr783) Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
PLCG1: a calcium dependent phosphatidylinositol-specific phospholipase C. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylated and activated by tyrosine kinases in response to signaling through a variety of growth factor receptors and immune system receptors.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase
Chromosomal Location of Human Ortholog: 20q12
Cellular Component: cell projection; cytoplasm; cytosol; intercellular junction; lamellipodium; plasma membrane; ruffle; signalosome
Molecular Function: calcium ion binding; glutamate receptor binding; neurotrophin TRKA receptor binding; phosphoinositide phospholipase C activity; phospholipase C activity; protein binding; protein kinase binding; receptor signaling protein activity; receptor tyrosine kinase binding
Biological Process: activation of MAPKK activity; axon guidance; calcium-mediated signaling; cell migration; cellular response to epidermal growth factor stimulus; epidermal growth factor receptor signaling pathway; Fc-epsilon receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; in utero embryonic development; inositol phosphate metabolic process; leukocyte migration; phospholipid catabolic process; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of epithelial cell migration; positive regulation of release of sequestered calcium ion into cytosol; signal transduction; T cell receptor signaling pathway; viral process
Research Articles on PLCG1
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Product Notes
The Human, Mouse, Rat PLCG1 plcg1 (Catalog #AAA9501029) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501029 ELISA Kit recognizes Human, Mouse, Rat PLCG1. It is sometimes possible for the material contained within the vial of "PLCG1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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