EPHA2/3/4 elisa kit
Phospho-EPHA2/3/4 (Tyr588/596) Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010]
Uniprot Description
EphA2: a receptor tyrosine kinase. Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A3, -A4 AND -A5. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. Overexpressed in many cancers including aggressive ovarian, cervical and breast carcinomas, and lung cancer. Expression correlates with degree of angiogenesis, metastasis and xenograft tumor growth. Soluble receptor inhibits tumor growth and angiogenesis in mice.
Protein type: EC 2.7.10.1; Eph family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 1p36.13
Cellular Component: cell surface; focal adhesion; integral component of plasma membrane; intracellular; lamellipodium; plasma membrane
Molecular Function: ATP binding; cadherin binding; ephrin receptor activity; protein binding; transmembrane receptor protein tyrosine kinase activity; viral receptor activity
Biological Process: angiogenesis; bone remodeling; cAMP metabolic process; cell adhesion; cell migration; cell motility; DNA damage response, signal transduction resulting in induction of apoptosis; entry of virus into host cell; ephrin receptor signaling pathway; keratinocyte differentiation; lens fiber cell morphogenesis; mammary gland epithelial cell proliferation; multicellular organism development; negative regulation of protein kinase B signaling cascade; osteoblast differentiation; osteoclast differentiation; peptidyl-tyrosine phosphorylation; protein kinase B signaling; regulation of angiogenesis; regulation of blood vessel endothelial cell migration; regulation of cell adhesion mediated by integrin; regulation of ERK1 and ERK2 cascade; regulation of lamellipodium assembly
Disease: Cataract 6, Multiple Types
Research Articles on EPHA2/3/4
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Product Notes
The Human, Mouse, Rat EPHA2/3/4 epha2 (Catalog #AAA9501294) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501294 ELISA Kit recognizes Human, Mouse, Rat EPHA2/3/4. It is sometimes possible for the material contained within the vial of "EPHA2/3/4, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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