BIM elisa kit
BIM Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]
Uniprot Description
BIM: a pro-apoptotic member of the BCL-2 protein family. Interacts with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and act as an apoptotic activator. Its expression can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role in neuronal and lymphocyte apoptosis. Transgenic studies in the mouse suggested that this protein functions as an essential initiator of the apoptosis in thymocyte-negative selection. Nineteen alternatively spliced transcript variants of this gene have been reported.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 2q13
Cellular Component: cytoplasmic dynein complex; cytosol; endomembrane system; extrinsic component of membrane; mitochondrial outer membrane; mitochondrion
Molecular Function: microtubule binding; protein binding; protein heterodimerization activity; protein kinase binding
Biological Process: apoptosis; apoptotic process involved in embryonic digit morphogenesis; B cell apoptosis; B cell homeostasis; brain development; cell-matrix adhesion; cellular process regulating host cell cycle in response to virus; cellular response to glucocorticoid stimulus; DNA damage response, signal transduction resulting in induction of apoptosis; ear development; in utero embryonic development; kidney development; lumen formation; male gonad development; mammary gland development; meiosis I; myeloid cell homeostasis; odontogenesis of dentine-containing teeth; pigmentation during development; positive regulation of apoptosis; positive regulation of apoptosis by virus; positive regulation of cell cycle; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; positive regulation of fibroblast apoptotic process; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of IRE1-mediated unfolded protein response; positive regulation of neuron apoptotic process; positive regulation of protein homooligomerization; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of release of cytochrome c from mitochondria; post-embryonic organ morphogenesis; protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; regulation of apoptosis; regulation of developmental pigmentation; regulation of organ growth; spermatogenesis; spleen development; T cell homeostasis; thymus development
Research Articles on BIM
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Product Notes
The Human, Mouse, Rat BIM bcl2l11 (Catalog #AAA9500064) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9500064 ELISA Kit recognizes Human, Mouse, Rat BIM. It is sometimes possible for the material contained within the vial of "BIM, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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