IQGAP1 blocking peptide
IQGAP1 Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008]
Uniprot Description
IQGAP1: Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth. Interacts with CDC42; the interaction is demonstrated with IQGAP1 in GTP-bound and in nucleotide-free state. Interacts with RAC1. Does not interact with RHOA. Interacts with TSG101. Interacts with PAK6. Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas.
Protein type: GAPs, Ras; Motility/polarity/chemotaxis; GAPs
Chromosomal Location of Human Ortholog: 15q26.1
Cellular Component: actin cytoskeleton; actin filament; axon; cytoplasm; cytosol; extrinsic to internal side of plasma membrane; focal adhesion; growth cone; lateral plasma membrane; microtubule; microtubule cytoskeleton; midbody; neuron projection; plasma membrane; protein complex; ruffle
Molecular Function: calcium ion binding; calmodulin binding; GTPase activator activity; GTPase inhibitor activity; phosphatidylinositol-3,4,5-triphosphate binding; protein binding; protein complex binding; protein domain specific binding; protein kinase binding; protein phosphatase binding; protein serine/threonine kinase activator activity; Rac GTPase binding
Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; negative regulation of dephosphorylation; platelet-derived growth factor receptor signaling pathway; positive regulation of GTPase activity; positive regulation of protein kinase activity; regulation of cytokine production; signal transduction; small GTPase mediated signal transduction
Research Articles on IQGAP1
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Product Notes
The IQGAP1 iqgap1 (Catalog #AAA427185) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The IQGAP1 Immunizing Peptide reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-KRQSGQTD PLQKEE. It is sometimes possible for the material contained within the vial of "IQGAP1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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